5alpha-reductase 2 inhibition impairs brain defeminization of male rats: Reproductive aspects

September 2005 in “ Pharmacology Biochemistry and Behavior ”

Camilla Moreira Ribeiro, Oduvaldo Câmara Marques Pereira

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research Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility

35 citations , October 2004 in “Biology of Reproduction”

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

research Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment

26 citations , July 1995 in “Neurobiology of Aging”

Finasteride affects prostate weights and pituitary activity differently with age.

research Finasteride

187 citations , January 1994 in “The New England Journal of Medicine”

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats

research Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats

26 citations , November 1993 in “Progress in Neuro-psychopharmacology & Biological Psychiatry”

Treatment during development affects hormone balance and sexual behavior in male rats.

research Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor

86 citations , March 1993 in “Toxicology and Applied Pharmacology”

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

research Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation

37 citations , January 1991 in “Reproductive Toxicology”

Finasteride reduces male rat fertility by causing issues with copulatory plug formation.

research External Genitalia Abnormalities in Male Rats Exposed In Utero to Finasteride, a 5α-Reductase Inhibitor

122 citations , July 1990 in “Teratology”

Finasteride exposure in pregnancy causes genital abnormalities in male rats.