Colorectal Cancer Co-opts an Epidermal Wound Healing Program During Metastasis to Generate Disseminated Tumor Cells

    July 2026 in “ Nature Communications ”
    Mizuho Sakahara, Takuya Okamoto, Kohei Kumegawa, Yasuko Natsume, Daisuke Kusama, Hitomi Yamanaka, Rie Komatsuzaki, Katsuyuki Yaginuma, Upasna Srivastava, Atsushi Takahashi‐Kanemitsu, Etsuo A. Susaki, Kazutaka Obama, Satoshi Nagayama, Reo Maruyama, Ryoji Yao
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    Studysummary In this study, researchers used patient-derived organoids to model metastasis in colorectal cancer and discovered that cancer cells temporarily switch to a wound-healing program, orchestrated by reduced EZH2 activity and YAP signaling, before spreading to new organs.
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