Copper-Doxorubicin as a Nanoparticle Cargo Retains Efficacy with Minimal Toxicity

    October 2010 in “ Molecular Pharmaceutics
    Azadeh Kheirolomoom, Lisa M. Mahakian, Chun-Yen Lai, Heather A. Lindfors, Jai Woong Seo, Eric E. Paoli, Katherine D. Watson, Eric M. Haynam, Elizabeth S. Ingham, Xing Li, R. Holland Cheng, Alexander D. Borowsky, Robert D. Cardiff, Katherine W. Ferrara
    Studysummary In this study, copper-doxorubicin liposomes with multidose therapy reduced systemic toxicity compared to ammonium sulfate-loaded doxorubicin liposomes, while combinatorial strategies further enhanced tumor regression and accumulation.
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