Three-Dimensional Bioprinted Non-Small Cell Lung Cancer Models in a Mouse Phantom for Radiotherapy Research

    September 2024 in “ International Journal of Molecular Sciences ”
    Yikun Mei, Elena Lakotsenina, Marie Wegner, Timon Hehne, Dieter Krause, Dani Hakimeh, Dongwei Wu, Elisabeth Schültke, Franziska Hausmann, Jens Kurreck, Beatrice Tolksdorf
    TLDR 3D bioprinted lung cancer models in a mouse-like structure offer a better way to study radiation effects without using live animals.
    This study introduces a three-dimensional (3D) bioprinted model of non-small cell lung cancer (NSCLC) embedded in a mouse phantom to enhance radiotherapy research. The model, which includes lung tumor cells and human primary lung fibroblasts, effectively simulates physiological conditions and radiation attenuation similar to real tissues. It demonstrates that 3D models better mimic clinical dose distribution and show more pronounced effects of radiotherapy, such as DNA damage and apoptosis, compared to traditional 2D cultures. This approach addresses the limitations of animal models and offers a promising alternative for studying radiation effects and developing new cancer treatments.
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