165 Single-cell RNA sequencing analysis unveils highly active yet diminished CD14+CD16- circulating monocytes, independent of alopecia areata severity
November 2023
in “
Journal of Investigative Dermatology
”
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Similar Research
5 / 1000+ resultsresearch Table 1_Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata.docx
July 2025 in “Figshare” Alopecia areata involves immune system changes, especially in severe cases, with potential new treatment targets identified.
research 164 Epigenetic and transcriptional profiling of PBMCs in mild and severe alopecia areata using single-cell RNA-Seq and ATAC-Seq
November 2023 in “Journal of Investigative Dermatology” This study utilized single-cell RNA sequencing and ATAC sequencing to analyze peripheral blood mononuclear cells from 6 mild alopecia areata (AA) patients, 5 severe AA patients, and 5 healthy controls, identifying 16 unique cell clusters among 32,084 cells. The research highlighted that over 80% of these cell types shared open chromatin regions linked to nine key transcription factors involved in various immune functions, such as T cell activation, dendritic cell maturation, and B cell maturation. The findings provide a detailed view of the transcriptional and epigenetic differences between mild and severe AA, offering insights for future research and potential therapeutic targets.
research Comprehensive single-cell transcriptomic profiling of the scalp from patients with moderate-to-severe alopecia areata
February 2026 in “Journal of Allergy and Clinical Immunology” Alopecia areata involves immune system issues and specific cell types that disrupt hair growth, leading to hair loss.
research Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing
23 citations , July 2023 in “Proceedings of the National Academy of Sciences” CD8+ T cells drive alopecia areata, while regulatory T cells are protective.