Association of One-Year Blood Pressure Variability With Long-Term Mortality Among Adults With Coronary Artery Disease

    April 2021 in “ JAMA Network Open
    Osama Dasa, Steven M. Smith, George Howard, Rhonda M. Cooper‐DeHoff, Yan Gong, Eileen Handberg, Carl J. Pepine
    TLDR Higher variability in systolic blood pressure increases long-term mortality risk in coronary artery disease patients.
    This study examined the link between 1-year blood pressure (BP) variability and long-term mortality in 16,688 adults with coronary artery disease. Over an average follow-up of 10.9 years, it was found that higher variability in systolic blood pressure (SBP) was significantly associated with increased long-term mortality, especially in women, even after adjusting for various factors. Four measures of BP variability were used, with average real variability (ARV) showing the strongest association. In contrast, diastolic BP variability did not show a significant link to mortality. The study suggested that minimizing SBP variability could be crucial in reducing mortality risk and emphasized the importance of incorporating BP variability measures in clinical practice to identify high-risk patients.
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