May the Best Wound WIHN: The Hallmarks of Wound-Induced Hair Neogenesis
February 2022
in “Current Opinion in Genetics & Development”
TLDR Wounds can cause new hair growth in adult mice, influenced by Wnt signaling.
The document discusses the process of wound-induced hair neogenesis (WIHN), a phenomenon where hair follicles regenerate in the wound bed of adult mice. This regeneration is dependent on the proportion of the wound to the body. The study by Ito and Cotsarelis showed that regenerated hair follicles originate from epithelial cells outside of the hair follicle stem cell (HFSC) niche. The Wnt signaling pathway plays a critical role in this process, with forced expression of the Wnt inhibitor, Dkk, preventing the formation of new hair follicles, while overexpression of Wnt7a led to a twofold increase in new hair follicles. The WIHN model is seen as a valuable platform for studying mammalian regeneration, with potential implications for the treatment of various scars and forms of alopecia.
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