Histogen Trial Shows 73% Increase in Hair After One Year and One Injection
[22 Apr 2010 | View Comments]
Histogen Trial Shows 73% Increase in Hair After One Year and One Injection

Histogen, a regenerative medicine company launched in 2007, has announced an encouraging follow-up to their pilot study from last year.

And it is good. Trialists were given only one application of Histogen’s Hair Stimulating Complex (HSC), and in some cases gained 73% more hair in the application area.
HSC seems to be a relabeled version of their ReGenica product [...]

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[ 11 Aug 2009 | View Comments ]

A few years ago, it seemed like Intercytex was going to provide mankind with the definitive solution to hair loss. The hair regeneration therapy, known as ICX-TRC, showed great promise: it was going to be cheaper, less uncomfortable and more effective than hair transplants. Results from clinical trials looked good and commercial application seemed to [...]

Video »

[ 4 May 2009 | View Comments ]
Hair Loss Video – MTV True Life: “I’m Losing My Hair”

MTV recently highlighted emotional struggles with hair loss in a documentary they regularly air, called “True Life”. This segment was about a 25 year old Floridian male coping with pattern loss that began in his teens. He had previously employed well-tread baldie tricks like sunglasses-on-the-hairline, which is a bit like bedazzling your goiter with diamonds, [...]

News »

[ 3 May 2009 | View Comments ]
Trial Volunteers Needed For Natural, Topical Hair Loss Treatment

The goal of HairGen is to reduce hair loss to non-MPB levels, while also creating a healthy scalp environment that may potentially promote thicker hair and/or regrowth.

The herbs used in HairGen are all wild-harvested, which, while more costly, ensures that each ingredient is of the very finest quality. All of the herbs are distilled into liquid extracts via pure organic grape spirits, and the alcohol will then be removed to ensure that no damage is done to the scalp.

The alcohol can be removed due to the unique cutting-edge liposomal delivery system that uses phospholipids to increase scalp permeability.

Opinion »

[ 20 Jan 2009 | View Comments ]
Some Guy Says He’s Going To Do Some Thing To Cure Hair Loss

Telegraph out of the UK reports that 27-year-old Oxford grad Thomas Whitfield (Myspace) is heralding an end to baldness as we know it, with a secretive new venture called TRX2:
Still in stealth mode as the intellectual property is in the process of being protected, Whitfield plans to have his “product and service” [...]

News »

[ 13 Aug 2008 | View Comments ]
Follica raises $11mil, reveals secret 11 herbs and spices

Right on the heels of previous funding, Follica has just announced the completion of a second round of funding, grabbing 11 million USD and G. Kirk Raab, ex-CEO of biotech giant Genentech as a chairman. Follica CEO Daphne Zohar heads up the publicity with an overview on Xconomy.com: “Our research has been progressing in a very positive way. We have had significant interest from the venture community and while we just closed the Series A round a few months ago …

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  • Blogspot.com - Soy Isoflavones and Chili Pepper for Hair Growth – Experiment Begins
    The hotter the pepper, the more capsaicin it contains. (Photo by Andreas Adermark)I've written so many posts on soy isoflavones and hair growth that I figured it's time to start another experiment to see for myself whether the claims are true.Even though it looks like soy isoflavones alone are sufficient to increase dermal levels of IGF-1 and thus promote hair growth, the most effective combination seems to be isoflavones and capsaicin. If you haven't seen the pictures from that paper for some reason, I recommend taking a look at the latter link. This combination is the one I will be testing.The soy isoflavones supplement I have is by NOW Foods. It contains 60 mg of isoflavones (genistein, daidzein and glycitein) per capsule. This is slightly less than the 75 mg used in the human study, but since I don't want to take 120 mg per day, it'll have to do.As for capsaicin, I'm going with the natural route and adding chili pepper to my foods during the experiment. There are capsaicin supplements too, but since I like spicy foods anyway, I don't think supplements are worth the extra money in this case.The only problem is that it's pretty difficult to estimate the amount of capsaicin; a tablespoon of ground chili will contain anywhere between 0.8 mg and 480 mg of capsaicin. In the study, 7 mg per day was consumed, so if I manage to eat a tablespoon, I should have decent odds of ingesting at least as much capsaicin. As you can see, this is not an exact replica of the human study, but I think my own experiment will be very close to what other people might try at home. The study lasted for 5 months, which is how long you should give any treatment before realistically expecting results. I will post an update after I run out of capsules and we'll see what happens then.Keep in mind that this is not the only thing I have going on at the moment that might affect hair growth. Though not technically experiments, I've been using ketoconazole and piroctone olamine shampoos regularly, because the science behind them looks pretty good. I'm also consuming some ground flax seeds every now and then, which could be beneficial for hair.Since I started to use these three things, I've noticed a slight decrease in the number of hairs lost daily. Whereas I counted 60-80 before, I now seem to lose about 40-50 hairs daily. Both of these figures are within the normal range, so these additions to my health regiment are mostly about preventing (or at least delaying) any future hair loss. Still, if the hair growth promoting effect of isoflavones and capsaicin is as strong as the rodent and human studies show, I would expect some visible changes even in people without androgenic alopecia.Lastly, my experiments with retinoids and an Ayurvedic topical called Nutrich oil are still running. I'm applying both of them on my temples, one on the left and the other on the right, to see if they increase hair growth. So far I have not noticed any dramatic changes, so I don't think they will obfuscate the results of this experiment too much.I'll keep you updated on how things go. Meanwhile, if you've tried soy isoflavones or capsaicin, drop a comment and share your experiences!For more information on hair growth, see these posts:BioSil, JarroSil & Beer – Silicon Experiment ConclusionEmu Oil vs. Hair Again® Topical Gel: Hair Growth Battle ConclusionEclipta Alba Extract Grows Hair Quicker than MinoxidilDo Flax Lignans Reduce Hair Loss from MPB?
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  • Blogspot.com - Soy Isoflavones Grow Hair by Increasing IGF-1 in the Skin
    Food sources of isoflavones include tofu and miso soup. (Photo by sokole oko)Many of you have probably heard that soy isoflavones may be good for hair loss. How exactly dietary isoflavones work to promote hair growth is less clear, however.As long-time readers may remember, I've written before about the effects of dietary isoflavones on humans and animals. For example, in male rats even a relatively low amount of soy isoflavones reduces DHT and increases testosterone. This alone would probably be enough to explain hair growth in rodents.Of course, humans are a more difficult case. Most of the things that show promise in mice or rats don't work for humans with androgenic alopecia in the end. The good news is that soy isoflavones reduce DHT even in humans. The bad news is that the reduction may not be great enough. About 60 mg of isoflavones daily reduced serum DHT in healthy young men by only 15%.Even this moderate drop would suggest a reduction in 5-alpha-reductase, which converts testosterone to DHT. However, the markers of 5-alpha-reductase looked at in the study did not show a difference between the treated and the control group.And yet, a combination of capsaicin and soy isoflavones grows hair in both animals and humans. In this study, capsaicin injected into the skin was enough to grow hair in animals, although the combination was more effective. In humans, orally administered isoflavones and capsaicin resulted in hair growth in 88% of the participants with androgenic alopecia, which is a remarkable result for a supplement that reduces DHT by so little.The authors speculated that capsaicin and soy isoflavones promote hair growth by increasing dermal levels of insulin-like growth factor (IGF-1). They suggested that a key factor was calcitonin gene-related peptide (CGRP), which acts as a vasodilator, among other things. It also increases IGF-1 in various tissues, including the skin.This theory is supported by the fact that subcutaneous capsaicin increased CGRP release and IGF-1 expression in hair follicle cells in normal mice but not in CGRP-knockout mice. Soy isoflavones increased the production of CGRP, which explains why the combination was more effective than capsaicin alone.Based on these studies, it was still unclear whether dietary isoflavones alone promote hair growth. Now, the same authors have investigated their idea further. In their new study, they fed isoflavones to mice whose backs were shaved and measured their hair growth (link). Again, both wild-type mice and CGRP-knockout were used.The isoflavone supplement used was Fujiflavone P40, which contains 43.5% isoflavones. 5 g of the product was mixed per each kg of standard chow. On average, the mice ate 4.6 grams of food daily, which means that their daily intake of isoflavones was 0.0046 * 0.005 * 0.435 = ~10 mg (correct me if my calculation is wrong).After three weeks of isoflavone administration, dermal CGRP and IGF-1 levels in wild-type mice increased significantly compared to the control group. In the knockout mice, no difference was seen between mice given isoflavones and the control group.Hair follicle number also increased in wild-type mice given isoflavones. Compared to the control group, they had about 40% more hair follicles. The knockout mice had less hair follicles to begin with, and when they were given isoflavones, no improvement was seen. Thus, it seems that isoflavones grow new hairs through increasing dermal levels of CGRP and IGF-1.Compared to the mice given isoflavones, the control mice seemed to take a longer time growing their existing hair back. Even the knockout mice that saw no increase in IGF-1 grew their hair back quicker when they were given isoflavones. This might be due to other effects of isoflavones, such as reducing DHT levels. Based on the pictures in the full paper, the wild-type mice grew their hair back even quicker, however. Wild-type mice given isoflavones also had a more pronounced darkening of hair than their control group.So what is the take home message? Based on all these studies, it looks like soy isoflavones show very good potential for promoting hair growth. A part of their effectiveness may come from the fact that they reduce serum DHT and increase testosterone, but based on the rodent data, the real kick is from the increase in skin levels of IGF-1.At the moment, there is no data comparing the effectiveness of soy isoflavones vs. capsaicin in humans. However, we do know that the combination is superior in increasing dermal IGF-1 in animals, and that the combination of both taken orally grows hair in humans with androgenic alopecia.For more information on hair growth, see these posts:Topical Retinoids Increase Hair Growth in Most People BioSil, JarroSil & Beer – Silicon Experiment ConclusionZinc Pyrithione Reduces Shedding and Moderately Promotes Hair GrowthHair Growth with Ayurveda – The Nutrich Oil Experiment
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