Regrowing hair with self-mutilation, Jackalopes and stem cells
[2 Mar 2008 | 5 Comments]
Regrowing hair with self-mutilation, Jackalopes and stem cells

50 years ago, the late cancer researcher Charles Breedis was taking a scalpel to the backs of rabbits at a University of Pennsylvania lab. Under a grant by the National Cancer Institute, he was investigating the link between healing and the Shope papilloma virus, a carcinogenic pathogen similar to HPV in humans .. Dr. Breedis had observed the first recorded instance of follicular neogenesis, a phenomenon in which new, fully functioning hair organs develop as a biproduct of trauma to the body.

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[ 4 May 2009 | 8 Comments ]
Hair Loss Video – MTV True Life: “I’m Losing My Hair”

MTV recently highlighted emotional struggles with hair loss in a documentary they regularly air, called “True Life”. This segment was about a 25 year old Floridian male coping with pattern loss that began in his teens. He had previously employed well-tread baldie tricks like sunglasses-on-the-hairline, which is a bit like bedazzling your goiter with diamonds, [...]

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[ 3 May 2009 | 4 Comments ]
Trial Volunteers Needed For Natural, Topical Hair Loss Treatment

The goal of HairGen is to reduce hair loss to non-MPB levels, while also creating a healthy scalp environment that may potentially promote thicker hair and/or regrowth.

The herbs used in HairGen are all wild-harvested, which, while more costly, ensures that each ingredient is of the very finest quality. All of the herbs are distilled into liquid extracts via pure organic grape spirits, and the alcohol will then be removed to ensure that no damage is done to the scalp.

The alcohol can be removed due to the unique cutting-edge liposomal delivery system that uses phospholipids to increase scalp permeability.

Opinion »

[ 20 Jan 2009 | 11 Comments ]
Some Guy Says He’s Going To Do Some Thing To Cure Hair Loss

Telegraph out of the UK reports that 27-year-old Oxford grad Thomas Whitfield (Myspace) is heralding an end to baldness as we know it, with a secretive new venture called TRX2:
Still in stealth mode as the intellectual property is in the process of being protected, Whitfield plans to have his “product and service” [...]

News »

[ 13 Aug 2008 | 4 Comments ]
Follica raises $11mil, reveals secret 11 herbs and spices

Right on the heels of previous funding, Follica has just announced the completion of a second round of funding, grabbing 11 million USD and G. Kirk Raab, ex-CEO of biotech giant Genentech as a chairman. Follica CEO Daphne Zohar heads up the publicity with an overview on Xconomy.com: “Our research has been progressing in a very positive way. We have had significant interest from the venture community and while we just closed the Series A round a few months ago …

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[ 8 Aug 2008 | One Comment ]
Platelet Rich Plasma – Industry magazine excerpts

Joseph Greco has been sending out some scans from a hair transplant industry magazine regarding Platelet Rich Plasma as used in hair transplant surgeries.

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    I’m currently a 3 on the Norwood scale and I see some miniaturization in my crown. Someday I’ll probably reach a 6 on the Norwood scale like my father did, but lets say for some reason I were to progress as far as a 7, when would that miniaturization be present? Would a doctor [...]
  • TheBaldTruth - Early Onset Male Pattern Baldness May Be Linked To Lower Incidence Of Prostate Cancer
    According to researchers at the University of Washington School of Medicine, men who develop early onset male pattern baldness had a significant reduction in the risk of prostate cancer. The researchers studied 2000 men aged 40 to 47. “At first, the findings were surprising,” said professor Jonathan Wright of the University of Washington School of Medicine in Seattle. “But [...]
  • Balding Blog - Was Propecia Working? I’m Scared to Quit!
    Hi i had a question about propecia. I used this (generic Finasteride) for nearly a year, however i never had any regrowth of hair. I seemed to maintain my hair to an extent, but i still was thinning. I’m curious do you think the medication was stopping my hairloss from progressing or is it more [...]
  • Balding Blog - Would Hair Regrow in a Scalp Scar?
    (female) I’d had a bald spot since birth, possibly a birthmark and possibly a scar from my extraction. At 20 I had an stapled excision. Now I’m curious, Is hair meant to grow in the area where the staples were, or will there always be a bald line? Is there anything I can do to [...]
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  • Balding Blog - Should We Bother Treating MPB?
    I just read this article about hair loss on MSN — The Naked Truth About Baldness They basically say that you shouldn’t bother medicating for MPB because the results aren’t worth it. They don’t even mention surgery as an alternative to medication. I was wondering if you believe this had any merit or if it is [...]
  • Balding Blog - My Hair Falls Out In The Same Months Each Year
    My hair seems to fall out every year and then it grows back. I can comb my hair and the comb is full of hair. Right know my hair is falling out and I noticed a bald spot on the left side of my head. I read so of the other people’s concerns and you [...]
  • Balding Blog - Do I Have a Funny Hairline or Am I Going Bald?
    Hey so I’ve always noticed that the right side of my hairline goes up a little farther than my left side. I’ve also noticed that the temple “triangle” has been shaped differently. As long as I can remember (and looking back at photos from when I was in HS), my hairline has never been straight. [...]
  • Balding Blog - In the News - Humans Regrowing Body Parts
    Snippet from the article: Researchers have found that the gene p21 appears to block the healing power still enjoyed by some creatures including amphibians but lost through evolution to all other animals. By turning off p21, the process can be miraculously switched back on. Academics from The Wistar Institute in Philadelphia found that mice lacking the p21 [...]
  • Balding Blog - After a Week on Propecia, My Hair Doesn’t Come Out When I Pull It
    Recently restarted Propecia on Dr. Bernstein’s advice. After one week, pulling out crown hair takes as much effort as hair in the permanent zone. Previously crown hair would come out with the slightest of force. Now it really hurts to pull crown hair like permanent zone hair. Does this mean it is working? Pity is, [...]
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    The Amazon customer feedback feature is great for helping you decide whether to buy a product or not. I just checked Regaine the hair loss treatment. All in all the customers who reported were pretty well pleased with the results. Some even reported that the hair loss stopped on the temples.
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    Androgenetic alopecia (AGA), commonly known as male pattern baldness, is a form of hair loss that occurs in both males and females. Although the exact cause of AGA is not known, it is associated with genetic predisposition through traits related to androgen synthesis/metabolism and androgen signaling mediated by the androgen receptor (AR). Current therapies for AGA show limited efficacy and are often associated with undesirable side effects. A major hurdle to developing new therapies for AGA is the lack of small animal models to support drug discovery research. Here, we report the first rodent model of AGA. Previous work demonstrating that the interaction between androgen-bound AR and beta-catenin can inhibit Wnt signaling led us to test the hypothesis that expression of AR in hair follicle cells could interfere with hair growth in an androgen-dependent manner. Transgenic mice overexpressing human AR in the skin under control of the keratin 5 promoter were generated. Keratin 5-human AR transgenic mice exposed to high levels of 5alpha-dihydrotestosterone showed delayed hair regeneration, mimicking the AGA scalp. This effect is AR mediated, because treatment with the AR antagonist hydroxyflutamide inhibited the effect of dihydrotestosterone on hair growth. These results support the hypothesis that androgen-mediated hair loss is AR dependent and suggest that AR and beta-catenin mediate this effect. These mice can now be used to test new therapeutic agents for the treatment of AGA, accelerating the drug discovery process. Crabtree J., Kilbourne E., Peano B., Chippari S., Kenney T., McNally C., Wang W., Harris H., Winneker R., Nagpal S., Thompson C. (Endocrinology. 2010 Mar 16; )
  • Pubmed - Phase I Evaluation of Telatinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Combination with Irinotecan and Capecitabine in Patients with Advanced Solid Tumors.
    PURPOSE: We studied the safety and tolerability of telatinib, an orally available, small-molecule tyrosine kinase inhibitor of the vascular endothelial growth factor receptor (VEGFR-2/VEGFR-3), platelet-derived growth factor receptor beta, and c-Kit in combination with capecitabine and irinotecan. EXPERIMENTAL DESIGN: Telatinib twice daily continuously, irinotecan once every 3 weeks, and capecitabine oral twice daily on day 1 to 14 were administered in cycles of 21 days in escalating doses in successive cohorts. Toxicity was evaluated to conform to the Common Terminology Criteria for Adverse Events version 3.0. Pharmacokinetic and (circulating) endothelial (progenitor) cell measurements were done. Tumor efficacy was evaluated using the Response Evaluation Criteria in Solid Tumors. RESULTS: Twenty-three patients were included in this phase I trial. Most frequently (>25%) reported adverse events of any grade were vomiting, nausea, fatigue, diarrhea, alopecia, and hand-foot syndrome. A silent myocardial infarction and two cases of decreased left ventricular ejection fraction were reported; both were reversible. Cardiac monitoring of the subsequent patients did not reveal other abnormalities. The study was terminated when the recommended single agent phase II doses of telatinib (900 mg twice daily) and capecitabine/irinotecan was reached. Pharmacokinetic profiles showed no clinically relevant changes upon coadministration of the three drugs. (Circulating) endothelial (progenitor) cell levels stabilized during treatment. Five of 23 patients had partial remission and 9 of 23 patients showed stable disease. CONCLUSIONS: Continuous administration of 900 mg telatinib twice daily can be safely combined with irinotecan (180 mg/m(2)) and capecitabine (1,000 mg/m(2) twice daily, day 1-14) and is the recommended schedule for further phase II studies. Tumor shrinkage and disease stabilization was observed. Cardiac toxicity needs further investigation in following studies. Clin Cancer Res; 16(7); OF1-11. Langenberg M., Witteveen P., Roodhart J., Verheul H., Mergui-Roelvink M., van der Sar J., Brendel E., Laferriere N., Schellens J., Voest E. (Clin Cancer Res. 2010 Mar 16; )
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