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The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Spironolactone most effective for hirsutism, but has side effects.

Lower SHBG levels may increase the risk of PCOS.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

PCOS in teens is hard to diagnose, linked to genetics and lifestyle, and managed with weight loss and medication.

Neurosteroids show promise for treating epilepsy and more research is needed.

Shift nurses show altered body temperature and stress hormone levels, suggesting their body clocks adjust to irregular schedules.

Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Single Blimp1+ cells can create functional sebaceous gland organoids in the lab.

Late pregnancy helps repair brain damage in rats due to the GABAergic system.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Hair disorders are caused by a complex mix of biology, genetics, hormones, and environmental factors, affecting hair growth and leading to conditions like alopecia.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Women with AGA have less hair on midscalp, more thin and non-growing hair.

High fasting insulin levels in women with PCOS are linked to a higher risk of heart and metabolic problems.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

Measuring the distance from the anus to the clitoris may moderately help diagnose polycystic ovary syndrome, especially in certain cases.

Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.

Obesity changes androgen levels in women with PCOS, leading to higher testosterone relative to androstenedione.

Alternative treatments show promise for hair growth beyond traditional methods.

A postmenopausal woman's hair loss and excess hair growth improved after surgery for ovarian hyperthecosis.

Low birthweight and rapid weight gain after birth may increase the risk of developing polycystic ovary syndrome.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.