June 2020 in “Annals of the Rheumatic Diseases” Patients with Systemic Sclerosis have much higher levels of GDF-15, which could help predict organ involvement and guide treatment.
June 2017 in “Poster presentations” All four treatments for early rheumatoid arthritis had similar safety profiles.
2 citations,
October 2022 in “Current Dermatology Reports” People on immune-modifying skin disease treatments may have a weaker antibody response to COVID-19 vaccines but often improve after the second dose.
1 citations,
March 2023 in “Clinical, Cosmetic and Investigational Dermatology” Current treatments for Alopecia Areata have mixed success, and there's a need for better, more accessible options and support for affected individuals.
A woman in Sri Lanka was diagnosed with lupus after presenting with protein loss from the gut and other symptoms.
1 citations,
June 2013 in “Annals of the Rheumatic Diseases” Methotrexate plus prednisolone had the fewest serious side effects.
Lupus nephritis patients face more challenges in family planning, work, symptoms, medication, and quality of life than those without it.
The study analyzed 312 systemic lupus erythematosus (SLE) patients treated with belimumab, focusing on different skin and joint manifestations. Results showed that belimumab was effective in reducing disease activity across various joint and skin phenotypes, with significant improvements in DAS28, SRI-4, and SLEDAI-2K scores. Notably, patients with acute and subacute skin manifestations responded earlier to belimumab compared to those with chronic skin phenotypes. However, no significant response was observed in patients with SLE-nonspecific skin manifestations alone. The study highlights the differential response to belimumab based on specific skin phenotypes in SLE patients.
The study on Anifrolumab treatment for systemic lupus erythematosus (SLE) patients revealed significant improvements in quality of life and a decrease in systemic corticosteroid use. Conducted through qualitative interviews with 14 patients and electronic medical record data from 16 patients, the research highlighted a reduction in bothersome symptoms such as fatigue, joint pain, and hair loss. Patients reported enhanced daily life activities, social interactions, and emotional well-being post-treatment. Additionally, clinical data showed decreased disease activity and improved laboratory results, supporting the subjective reports of symptom alleviation. These findings underscore the efficacy of Anifrolumab in managing SLE.
A survey conducted by Arthritis Ireland in late 2023, involving 57 respondents, revealed that lupus significantly impacts various aspects of life, including daily activities, family life, work, and mental health. Joint pain (88%) and extreme tiredness (86%) were the most common symptoms. Despite 93% being prescribed medication, 70% still experience flares at least every 3 months, and 45% report significant medication side-effects. The survey highlighted the importance of self-management, with 85% of respondents aware of its role. The findings underscore the substantial personal and financial costs of inadequate lupus treatment.
June 2016 in “Annals of the Rheumatic Diseases” Long-term glucocorticoid use can cause skin problems like easy bruising and poor wound healing, especially at higher doses.
June 2016 in “Annals of the Rheumatic Diseases” June 2015 in “Annals of the Rheumatic Diseases” 1 citations,
May 2021 in “Annals of the rheumatic diseases” Tofacitinib is a promising treatment for children with rheumatic diseases.
1 citations,
June 2020 in “Annals of the rheumatic diseases” Most patients successfully switched from the original adalimumab to a biosimilar with few reverting due to reduced effectiveness or side effects.
A high fat lard diet may protect against skin fibrosis and affect hair growth.
Older men with late-onset lupus have a higher mortality rate than women.
COVID-19 vaccines had more side effects and worse perception than flu vaccines in Korean lupus patients.
May 2022 in “Annals of the Rheumatic Diseases” It's unclear if COVID-19 vaccination causes SLE; more research is needed.
June 2020 in “Annals of the Rheumatic Diseases” Patients need better information about the risks of long-term steroid use.
June 2019 in “Poster presentations” Low dose methotrexate does not increase hair fall and may reduce it.
A TNFAIP3 gene mutation can cause unusual and varied symptoms of lupus and Sjogren's syndrome.
June 2016 in “Annals of the rheumatic diseases” Methotrexate is effective for treating rheumatoid arthritis but requires regular monitoring.
June 2013 in “Annals of the rheumatic diseases” Methotrexate dose has little effect on its toxicity when used with adalimumab for early rheumatoid arthritis.
June 2013 in “Annals of the Rheumatic Diseases” 6 citations,
January 2014 in “Joint Bone Spine” Tocilizumab treatment was associated with significant hair regrowth in one patient and temporary hair loss followed by regrowth in another.
144 citations,
November 2020 in “Frontiers in immunology” Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.
119 citations,
January 2012 in “Nutrition & Metabolism” Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.