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Novel Progestogenic Androgens for Male Contraception: Design, Synthesis, and Activity of C7 Alpha-Substituted Testosterone

research Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone

September 2023 in “Biology of reproduction”

This study suggests that the testosterone analogs 7α-Methyltestosterone and 7α-Ethyltestosterone may offer promising androgenic, progestogenic, and anabolic properties for development as male contraceptives.

research [Anti-androgens. Their use in dermatology].

January 1981 in “PubMed”

This study found that cyproterone acetate with ethynyl estradiol improved acne and seborrhea within 3–6 months in women, but had less satisfactory results for alopecia and hirsutism.

research Treatment of androgen excess in females: Yesterday, today and tomorrow

9 citations , January 1997 in “Gynecological Endocrinology”

This review discusses the regulation of hair growth, causes of excessive androgen secretion, and current safe solutions for hyperandrogenism manifestations in women but reports no new clinical results.

research Pharmacology of antiandrogens

97 citations , November 1986 in “Journal of Steroid Biochemistry”

This review discusses the pharmacological properties and clinical applications of cyproterone acetate and similar antiandrogens, noting previous failures in local applications due to concentration limitations; it reports no new empirical results.

Hormonal Activity in Commonly Used Black Hair Care Products: Evaluating Hormone Disruption as a Plausible Contribution to Health Disparities

research Hormonal activity in commonly used Black hair care products: evaluating hormone disruption as a plausible contribution to health disparities

25 citations , May 2021 in “Journal of exposure science & environmental epidemiology/Journal of exposure science and environmental epidemiology”

This study found that hair products commonly used by Black women exhibited hormonal activity, which could impact health outcomes and contribute to health disparities.

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Learn

5 / 801 results

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

learn dehydroepiandrosterone

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

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Community Join

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community Reversing Hairloss with 7α-Methyl-19-Nortestosteron aka Trestolone

7 upvotes 1 year ago

The user experienced significant hair regrowth using Trestolone, GHK-Cu, and Minoxidil. They avoided Finasteride due to concerns about side effects and noted that their approach reduced androgenic load, contributing to hair regrowth.

community Are these a good on, what’s your opinion?

2 upvotes 1 year ago

Progesterone, hydrocortisone butyrate, and estrone base are discussed as treatments for hair loss. Topical progesterone and dutasteride are suggested to potentially reverse androgenic alopecia.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

5 upvotes 2 years ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community For those that have used anti androgens what is your experience?

19 upvotes 2 years ago

People discussed their experiences with anti-androgens for hair loss, mentioning side effects like chest pains with RU58841 and skepticism due to lack of safety data, while considering Fluridil as a potential addition to treatment. Some users expressed reluctance to use these chemicals.

community Does anyone have any experience with Estradiol, Cyproterone Acetate, Spironolactone, Bicalutamide ?

4 upvotes 6 years ago

Some users have experienced good hair regrowth with estradiol, cyproterone acetate, spironolactone, and bicalutamide, but these treatments may cause feminization and other side effects. It's advised to consult a doctor before using these treatments, as they can lower testosterone and have significant risks.

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