research Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System
EGFR-TKIs can cause significant skin, nail, and organ side effects.
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research Dermatologic Adverse Events in EGFR-TKIs: A Real-World Analysis
EGFR-TKIs can cause unexpected skin, nail, and hair issues.
research Identifying SARS-CoV-2 Entry Inhibitors Through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles
The study identified six compounds—cepharanthine, abemaciclib, osimertinib, trimipramine, colforsin, and ingenol—as broad-spectrum inhibitors of spike-mediated cell entry in SARS-CoV-2, SARS-S, and MERS-S pseudotyped particles. These findings were based on a high throughput screen of an approved drugs library. The research aimed to contribute to the development of effective treatments targeting the initial stage of viral infection, potentially reducing the viral burden in COVID-19 patients.
research Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs
Spironolactone may make some cancer treatments more effective by blocking a protein that helps cancer cells survive.
research Target-Adverse Events and Fear of Cancer Progression, Anxiety, and Depression in Patients with Advanced Non-Small Cell Lung Cancer
Adverse events in lung cancer treatments increase fear, anxiety, and depression, with newer therapies causing fewer side effects.
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