January 2016 in “Human & Experimental Toxicology” A specific DNA sequence caused hair loss in male mice by activating immune cells and increasing a certain immune signal.
79 citations,
December 2013 in “Journal of Investigative Dermatology Symposium Proceedings” The document explored the pathogenesis of alopecia areata (AA) as an autoimmune disease mediated by CD8+T cells, emphasizing the collapse of hair follicle immune privilege (HF-IP) as a crucial factor. It identified natural killer group 2D-positive (NKG2D+) cells and their ligands as significant contributors to HF-IP collapse and AA phenotype induction. The study suggested that therapeutic strategies should focus on restoring HF-IP and modulating immune responses, potentially involving nonspecific suppression of the HF response to inflammatory stimuli. It also noted the potential roles of IFN-γ, substance P, and mast cells in AA development, proposing that effective management might require a broader approach beyond targeting specific autoantigens and T cells.
139 citations,
October 2005 in “Journal of Investigative Dermatology” The nail matrix has a reduced immune response, protecting it from autoimmunity.
2 citations,
January 2017 in “Clinical and medical investigations” Herbal lotions are effective for severe hair loss, with a 64.8% success rate, but relapse is common and long-term management requires allergen control and possible corticosteroid use.
54 citations,
September 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” Vitamin A affects hair loss and immune response in alopecia areata.