The hairless protein (HR), part of the jumonji family, was believed to regulate hair cycling through a stem cell-mediated process. Mutations in the Hr gene led to hair loss in both mice and humans. HR interacted with the vitamin D receptor (VDR) and histone deacetylase (HDAC) family members, acting as a nuclear receptor corepressor to regulate gene expression involved in hair cycling. However, the specific roles of the JmjC domain of HR and its subcellular localization in chromatin regulation remained unclear.
178 citations
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May 2006 in “Developmental Dynamics” Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.
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January 2010 in “Veterinary pathology” A new mutation in the hairless gene causes hair loss and skin wrinkling in mice.
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November 2020 in “International Journal of Molecular Sciences” Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
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September 2010 in “Annual Review of Genomics and Human Genetics” The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.