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Inner Root Sheath

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research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle

93 citations , July 2006 in “Journal of Investigative Dermatology”

K25, K27, and K28 are found in all inner root sheath layers of hair, while K26 is only in the cuticle.

Fine Structure and Immunocytochemistry of Monotreme Hairs, with Emphasis on the Inner Root Sheath and Trichohyalin-Based Cornification During Hair Evolution

research Fine Structure and Immunocytochemistry of Monotreme Hairs, with Emphasis on the Inner Root Sheath and Trichohyalin-Based Cornification During Hair Evolution

15 citations , July 2004 in “Journal of morphology”

Monotreme hair structure and protein distribution are similar to other mammals, but their inner root sheath cornifies differently, suggesting a unique evolution from reptile skin.

research Formation of surface membranes in developing mammalian hair fibres

30 citations , January 1994 in “Micron”

Mature hair surfaces are formed by keratinized cells with developed layers, not just modified plasma membranes.

research Location of Keratin-Associated Proteins in Developing Fiber Cuticle Cells Using Immunoelectron Microscopy

10 citations , January 2010 in “International journal of trichology”

Keratin-associated proteins are part of the developing hair fiber cuticle.

research The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice

73 citations , May 2009 in “Proceedings of the National Academy of Sciences”

Disrupting the Sox21 gene in mice causes hair loss and regrowth cycles.

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community Any news on potential hair loss treatments?

in Research/Science 13 upvotes 1 year ago

The conversation is about seeking updates on new hair loss treatments, specifically mentioning scube3 and GT20029, with one person mentioning HMI_115 as showing promising results.

community Doing sulforaphane since 2 weeks got new babyhairs

in Product 10 upvotes 4 years ago

The user noticed new baby hairs after using sulforaphane but is still experiencing shedding. They are seeking a supplement to stop shedding, possibly grape seed extract.

community 22 Years Old, 4 Months Of Minoxidil.

in Update 670 upvotes 4 years ago

The user's experience using Minoxidil to treat hair loss, with discussion of Finasteride and RU58841 as additional treatments. Additional advice is provided on ketozolin shampoo use and microdosing finasteride.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 59 upvotes 4 weeks ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community 2 years of fin, 1.5 years of minoxidil, calling it quits. Thank you.

in Shaved/buzzed 567 upvotes 2 years ago

This user has been struggling with hair loss for the past two years and attempted to treat it using finasteride and minoxidil. Despite their efforts, they have not seen any improvement in their condition, so they have decided to shave or buzz their head instead. Others gave advice on other treatments that could be tried if desired.

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