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This letter discusses observations of indinavir's effects on skin, likening them to those of retinoids, but does not present new clinical findings.

This study observed that patients undergoing indinavir/ritonavir therapy for HIV-1 frequently experienced reversible alopecia, likely due to retinoid-like effects, but these were independent of other retinoid-like skin manifestations.

This case report describes a black HIV-2 patient who experienced reversible nail, hair, and skin hyperpigmentation linked to ritonavir-boosted indinavir therapy, which resolved after discontinuation.

This case report presents an HIV-1 patient who experienced osteosclerosis and new bone formation potentially due to long-term indinavir therapy and concurrent use of vitamin A, with symptoms reducing after switching to nelfinavir.