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research Decision letter: IL18 signaling promotes homing of mature Tregs into the thymus

May 2020

In this study, researchers identified IL18R+ thymus-resident regulatory T cells in mice, demonstrating their unique molecular features and resistance to age- and stress-induced thymus involution, highlighting IL18 signaling's role in Treg migration and retention.

Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

research Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study identifies gene-regulatory networks related to genetic variants in skin and hair diseases, suggesting that dermal papilla cells are crucial in androgenetic alopecia.

research Author response: IL18 signaling promotes homing of mature Tregs into the thymus

July 2020

This study found that IL18 signaling plays a crucial role in the homing and retention of mature regulatory T cells in the mouse thymus, primarily by upregulating the chemokine receptor CCR6.

research Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome

21 citations , June 2016 in “Reproductive Sciences”

This study found increased IL-18 levels in the endometrium of women with polycystic ovary syndrome, especially in those who are overweight, suggesting a link with body mass index.

research IL-17 axis is a significant driver of skin inflammation in Card14 mutant pityriasis rubra pilaris model mice

February 2023 in “Research Square (Research Square)”

This study reports that a new mouse model with a CARD14 mutation successfully mimics key human PRP symptoms, and anti-IL-17A antibody significantly reduces these symptoms.

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Experts

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community Il PP405 è molto promettente ma non è l'unico in grado di liberarci dalla iattura

3 upvotes 1 year ago

PP405 shows promise in hair loss treatment, but stem cell therapy using adipose-derived stem cells and ATP also successfully reversed androgenetic alopecia in mice. Stem cell therapy is costly, and some doubt the effectiveness of PP405 based on press releases.

community Today I received my first Batch Follicopeptide

in Treatment 139 upvotes 7 months ago

A user purchased an expensive hair loss treatment called Follicopeptide, which many others in the conversation believe to be a scam, suggesting instead the use of proven treatments like minoxidil and finasteride. Some users report positive effects from Follicopeptide, but skepticism remains high due to lack of transparency about its ingredients and the company's credibility.

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Clinics

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