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NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types

research NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types

23 citations , September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this mouse study, NF-κB was shown to play a role in hair follicle cycling and morphogenesis, with specific activity patterns differing by hair type and involving noncanonical signaling for zigzag hair bending.

research Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice

63 citations , April 2005 in “Mechanisms of development”

This study found that heterozygous mice overexpressing Claudin-6 experienced alterations in epidermal and hair follicle differentiation, leading to distinctive coat characteristics and a disrupted epidermal permeability barrier.

research Pelage and molt in the black-tailed deer (Odocoileus hemionus (Rafinesque))

25 citations , May 1972 in “Canadian journal of zoology”

This study describes the pelage cycle, hair types, and molt patterns in black-tailed deer, highlighting significant differences in hair properties among various developmental stages and populations.

research Sensory innervation of the hairs of the rat hindlimb: A light microscopic analysis

43 citations , November 1988 in “The Journal of Comparative Neurology”

This study examined the sensory innervation of hair follicles in the furry skin of rat hindlimbs, finding significant differences among hair types in their innervation patterns and densities.

research Pelage cycle in blue fox(Alopex lagopus):A comparison between animals born early and late in the season

11 citations , May 1998 in “Acta agriculturæ Scandinavica. Section A, Animal science”

This study observed that pelage development in male blue foxes born in early June was more synchronized than those born in early May, with differences likely influenced by melatonin levels.

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Community Join

5 / 117 results

community Pelage, PP405, is creating a database for potential new trial volunteers

148 upvotes 11 months ago

PP405 is a new hair loss treatment targeting dormant hair follicles, with ongoing trials. Some users consider stopping finasteride and minoxidil to join trials, while others doubt its effectiveness.

community Why do some people (specially those with diffuse balding) experience more regrowth just with DHT blockers?

in Chat 41 upvotes 1 year ago

Diffuse thinners often experience more hair regrowth with DHT blockers like finasteride, possibly due to less DHT sensitivity and the presence of miniaturized, not completely bald, follicles. However, regrowth varies widely among individuals, influenced by factors like genetics, the stage of hair loss, and treatment methods such as minoxidil, microneedling, and dermarolling.

community Dutasteride is not maintaining my hair. What are some other good options?

in Treatment 2 upvotes 11 months ago

The user is experiencing diffuse hair loss despite using finasteride and dutasteride and is considering adding minoxidil, microneedling, or RU58841. They are also thinking about increasing the dutasteride dose or opting for a hair transplant, while being cautious about side effects.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community Reversing 8 years of hair loss. Dut is freaking magic!

4082 upvotes 1 year ago

A user successfully reversed hair loss over 17 months using 0.5mg dutasteride and 5mg oral minoxidil daily, noting significant improvement without a transplant. Minor side effects like headaches and testicular discomfort were reported but resolved quickly.

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Clinics

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All 39 clinic results →

Learn

9 / 801 results

learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

learn Latanoprost

glaucoma medication with hair follicle stimulant effects

learn Trichogen® (foligain)

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

learn Bimatoprost

a synthetic prostamide used to treat eyelashes also shows promise for stimulating hair growth on scalp

learn PP405

Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

learn Caffeine

Does the caffeine in the scalp reach the follicles or stay on the surface? Caffeine can penetrate the scalp and reach hair follicles.
Does caffeine stimulate hair growth or only slow hair loss? Caffeine stimulates hair follicles in laboratory cultures, and one open-label trial in 210 men found a 0.2% caffeine topical non-inferior to minoxidil 5% on an anagen-ratio endpoint; there is no placebo-controlled evidence that it regrows hair, and none at all in alopecia areata or telogen effluvium.

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Experts

2 / 17 results