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GlossaryFibroblast Growth Factor Receptor 1 (FGFR1)

protein involved in cell growth and tissue repair

Fibroblast Growth Factor Receptor 1 (FGFR1) is a protein that plays a crucial role in cell growth, development, and tissue repair by binding to specific growth factors. It is involved in various biological processes, including the development of the nervous system and the regulation of hair growth. Mutations or dysregulation of FGFR1 can lead to developmental disorders and contribute to conditions like cancer.

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research Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization

24 citations, July 2017 in “Structure”

FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.

research Careless Talk Costs Lives: Fibroblast Growth Factor Receptor Signalling and the Consequences of Pathway Malfunction

119 citations, November 2014 in “Trends in Cell Biology”

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

research FGF Family: From Drug Development to Clinical Application

103 citations, June 2018 in “International Journal of Molecular Sciences”

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

research Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

27 citations, February 2017 in “Clinical, Cosmetic and Investigational Dermatology”

New compounds were found to help increase hair growth and decrease hair loss.

research Friends Turned Foes: Angiogenic Growth Factors Beyond Angiogenesis

24 citations, October 2017 in “Biomolecules”

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

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