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GlossaryDystrophic Epidermolysis Bullosa (Dystrophic EB)

rare genetic disorder causing fragile, blistering skin from minor trauma

Dystrophic Epidermolysis Bullosa (DEB) is a rare genetic disorder characterized by extremely fragile skin that blisters and tears from minor friction or trauma. This condition is caused by mutations in the COL7A1 gene, which affects the production of type VII collagen, a protein essential for anchoring the layers of skin together.

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research Phenotypic Heterogeneity of Epidermolysis Bullosa Associated With the Recurrent Pathogenic Variant p.(Arg2000Trp) in Plectin

April 2023 in “Journal of Investigative Dermatology”

The specific skin disease variant p.(Arg2000Trp) in plectin can cause a wide range of symptoms, which should be considered when diagnosing patients.

research Clinical and Molecular Features in a Cohort of Middle Eastern Patients With Epidermolysis Bullosa

October 2023 in “Pediatric dermatology”

Middle Eastern patients with epidermolysis bullosa show specific genetic mutations linked to different types of the disease.

research Dominant Dystrophic Epidermolysis Bullosa: Seven Familial Cases

February 2009 in “Journal of The American Academy of Dermatology”

The document concludes that detailed clinical descriptions of seven family cases help understand dominant dystrophic epidermolysis bullosa's symptoms and inheritance.

research Inherited Epidermolysis Bullosa: Clinical and Therapeutic Aspects

32 citations, April 2013 in “Anais Brasileiros de Dermatologia”

The document concludes that inherited epidermolysis bullosa is a challenging genetic condition requiring multidisciplinary care and new treatments.

research First Symposium on Natural Gene Therapy of the Skin

9 citations, March 2012 in “Experimental dermatology”

Natural gene therapy shows promise for treating skin disorders like epidermolysis bullosa.

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community Is it possible to create an estrogen mesotherapy/topical that doesn't go systemic?

in Research/Science 6 upvotes 3 months ago

The conversation discusses the potential of using topical estrogen treatments for hair loss without systemic absorption, highlighting challenges and possible solutions like using estriol. It also mentions other treatments like topical finasteride, microneedling, and scalp massage, while noting the limitations and side effects of current options.

community Losing ground on dut, daily for 5 months after fin and min for a year.

in Finasteride/Dutasteride 92 upvotes 3 months ago

The user experienced increased hair thinning after switching from finasteride and minoxidil to dutasteride, despite some users suggesting it might be a temporary shedding phase. The user is considering using RU58841 but is unsure about its safety.

community Hairloss is mentally exhausting

in Chat 25 upvotes 4 years ago

The conversation is about the mental toll of hair loss and seeking alternatives to finasteride. Suggestions include using minoxidil, considering pumpkin seed oil, and possibly seeking counseling for body dysmorphic disorder.

community 5.5 months on oral min questions. Please help😭

in Treatment 11 upvotes 6 months ago

The user has been on finasteride for over a year and switched from topical to oral minoxidil five months ago, but is unsure if the current shedding and small hairs are signs of improvement or worsening. They are seeking advice on whether to wait longer or switch treatments.

community These two strands of hair refuse to give in to DHT for some reason.

in Satire 991 upvotes 6 months ago

The conversation humorously discusses two resilient hair strands that resist DHT, with mentions of minoxidil and finasteride as ineffective treatments. Users joke about cloning the hairs and the mystery of baldness.

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