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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 4 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community 6 Months Min and 3 Months Fin Results

      in Progress Pictures  192 upvotes 5 months ago
      User shared progress pictures showing significant hair improvement after 6 months of Minoxidil and 3 months of Finasteride, along with dermastamping twice a week. Another user encouraged them to continue the good work.

      community I can't take care of myself because of hair loss.

      in Chat  165 upvotes 6 months ago
      The conversation is about a user feeling hopeless due to hair loss despite using finasteride, dutasteride, and OM for over a year. Responses suggest therapy, self-improvement, and changing perspectives on appearance.

      community Finasteride won’t make all your problems go away

      in Finasteride/Dutasteride  323 upvotes 1 year ago
      A user shared that while finasteride improved their hair, it didn't solve all their insecurities, suggesting that self-acceptance is key. Others in the conversation expressed varying opinions, with some feeling that finasteride significantly boosted their confidence and quality of life, while others acknowledged it as a solution to hair loss but not a cure-all for other personal issues.

      community What an amazing time to be alive

      in Finasteride/Dutasteride  183 upvotes 1 year ago
      The post discusses a user's experience with hair loss treatments, specifically topical finasteride, minoxidil, and micro-needling, and their plan to switch to oral versions and add Dutasteride. The conversation includes various responses, with some users sharing their own experiences and side effects, and others expressing desire for a more permanent hair loss solution.

      community My Experience With Finasteride

      in Research/Science  21 upvotes 1 year ago
      A user shared their experience with Finasteride for hair loss, noting a significant reduction in DHT levels and a complete loss of libido without other side effects. Another user agreed, discussing the negative impact on sexual drive and criticizing the community's attitude towards discussing side effects.

      community [progress] Finasteride 42 MONTHS update

      in Update  67 upvotes 1 year ago
      The user's 42 month experience using finasteride for hair loss, their opinion on minoxidil use and the potential of pyrilutamide and another Chinese drug as treatments.

      community Vitamin D advice I received after seeing my blood work.

      in Research/Science  88 upvotes 3 years ago
      The conversation discusses the importance of taking vitamin D with food for better absorption and its potential role in hair loss. Some users also suggest taking vitamin D with K2, getting sunlight, and using finasteride for hair loss treatment.

      community When I was in my 20s, skinny and with long hair, one of my biggest fear was being fat and bald in my 40s. Now that it’s come to pass, I’ve found there are better things to worry about. I started shaving my head in 05 when I was 32 and I can sum it all up in one word: Liberating.

      in Shaved/buzzed  478 upvotes 3 years ago
      Accepting hair loss, with solutions discussed including Minoxidil and Finasteride treatments, shaving the head as a liberating experience, and using beards to make up for lack of hair.

      community Why isnt topical fin talked about more?

      in Chat  44 upvotes 1 month ago
      Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

      community The "I just want hair until im 30" cope.

      in Chat  221 upvotes 2 months ago
      Participants want to maintain hair until at least age 30, using treatments like finasteride, dutasteride, and minoxidil. Hair loss remains a concern, with some considering hair transplants.

      community If you gentlemen are balding like myself, I encourage you to try shaving.

      in Shaved/buzzed  1599 upvotes 2 months ago
      A user encouraged others experiencing hair loss to try shaving their heads, sharing their own positive experience despite briefly using finasteride and natural methods. Responses were mixed, with some supporting the decision and others suggesting treatments like minoxidil and finasteride, while many commented on the appearance changes.

      community I'm sorry I hate it, I cannot enjoy life like this.

      in Chat  175 upvotes 3 months ago
      A 22-year-old male is frustrated about being the only bald person in his social circle. He has tried minoxidil, finasteride, and dutasteride without success and is considering hair systems, transplants, or counseling.

      community 20yo, dutasteride and minoxidil aren’t working

      in Finasteride/Dutasteride  117 upvotes 3 months ago
      A 20-year-old reports worsening hair loss despite using dutasteride and minoxidil, and considers a hair transplant. Users suggest continuing treatments, trying microneedling, ketoconazole shampoo, switching to finasteride, or adding tretinoin.

      community High Nicotine use and Hair Loss

      in Chat  82 upvotes 4 months ago
      Heavy nicotine use can lead to hair thinning and loss, but quitting can reverse these effects. The user noticed significant hair regrowth after quitting vaping.

      community Embraced baldness. Time to leave this subreddit

      in Chat  876 upvotes 4 months ago
      A user shared their positive experience of embracing baldness after years of trying treatments like Minoxidil and finasteride. They found happiness and confidence by shaving their head, despite some social challenges, and encouraged others to focus on their attitude and seek therapy if needed.

      community 1 month of using fin, so happy

      in Progress Pictures  865 upvotes 4 months ago
      User had a hair transplant and used a finasteride and minoxidil spray for 6 months with no results. After adding finasteride tablets for 1 month, they saw significant hair growth improvement.

      community Finasteride progress 0.25-0.5mg 11 months

      in Progress Pictures  378 upvotes 5 months ago
      User shared progress pictures showing significant hair improvement after using finasteride (0.25-0.5mg daily) for 11 months. Other treatments like microneedling, ketoconazole, and scalp massage were mentioned but not used consistently.

      community Don't give up! 9 months on Minoxidil

      in Progress Pictures  392 upvotes 7 months ago
      A trans man shared progress pictures showing significant hair regrowth after 9 months on oral Minoxidil and 1.5 years on finasteride. He encourages others to stick with their treatments despite initial setbacks.

      community My mum is mad annoying about Fin.

      in Chat  245 upvotes 7 months ago
      A 25-year-old man discusses his struggles with his mother's opposition to his use of Finasteride for hair loss treatment, despite it improving his condition and self-control after a hair transplant. He expresses frustration over her blaming the medication for various issues and the stress caused by her insistence to stop taking it.

      community Post Finasteride Syndrome, A dangerous lie.

      in Chat  142 upvotes 10 months ago
      A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.