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GlossaryPyrilutamide

topical treatment blocking androgen receptors to combat hair loss

Pyrilutamide, also known as KX-826, is a topical non-steroidal anti-androgen being developed for the treatment of androgenetic alopecia (pattern hair loss). It works by blocking androgen receptors in hair follicles, which can help reduce hair loss and potentially promote hair regrowth.

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community Binding affinity does not equal potency for anti androgens? Comparing pyrilutimide to cb-03-01

in Research/Science 8 upvotes 2 years ago

Pyrilutimide and CB-03-01, two treatments for hair loss, have similar clinical trial results despite different binding affinities to androgen receptors. Factors other than binding affinity, like the time a drug stays bound to the receptor, may influence their effectiveness.

community Starting Pyrilutimide 5% Update

in Treatment 1 upvotes 11 months ago

The user started using Pyrilutamide 5% for hair loss and has not experienced side effects after two days. They previously had side effects from Fluridil and topical Minoxidil 5%, and their hair continued thinning with topical Spironolactone.

community C60 + microneedling – on off days from Pyrilutimide

in Microneedling 1 upvotes 1 year ago

User discusses using C60 serum with microneedling at 1.75mm and asks if it's safe. Current routine includes daily Pyril on temples, weekly microneedling, and C60 serum on non-Pyril days.

community Boys how is no one seeing positive results from pyrilutamide

in Chat 27 upvotes 1 year ago

Pyrilutimide, a treatment for hair loss; it's effectiveness compared to other treatments such as Finasteride and RU58841; and some users’ experiences with the treatment.

community Is there a consensus on RU these days? Pyril turned out to be a bust right?

in Research/Science 16 upvotes 8 months ago

The conversation discusses the effectiveness and safety of hair loss treatments, specifically RU58841 and Pyrilutimide (Pyril), with users sharing that Pyril was no more effective than a placebo and expressing concerns about the safety of RU58841 based on personal experiences and the lack of pharmaceutical interest.

community questions for the pyrilutamide users here

in Treatment 7 upvotes 1 year ago

The conversation discusses the storage and use of pyrilutamide for hair loss, where one user advises against keeping it in the freezer as it may crystallize the active compounds.

community is there a pyrilutamide group/discord to discuss results?

in Research/Science 21 upvotes 2 years ago

Discussing results, side effects and potential sources of pyrilutamide for hair loss treatment alongside RU58841 and other treatments such as Minoxidil and finasteride.

community Is treatment working? What else should I add?

in Is this regrowth? 2 upvotes 1 year ago

User started treatment with Fin and Min in 2022, added stemoxydine, and considering dut. They are unsure about microneedling due to scarring concerns.

community Topical spironolactone - anti androgen

in Research/Science 9 upvotes 2 years ago

User asks about topical spironolactone experience. Two studies show it as promising anti-androgen treatment, with 5% cream available on Minoxidilmax website.

community Been on Min and Fin for Years and I am Devastated.

in Treatment 64 upvotes 2 years ago

Guyman567 has been using oral finasteride and topical minoxidil for years but continues to experience hair loss and thinning, which has affected his confidence. He has tried various treatments including topical finasteride, microneedling, and vitamins, and is considering a hair transplant but is concerned about ongoing hair loss.

community My experience with 0.25mg Finasteride, Minoxidil induced lupus, and < 10mg RU58841.

in Treatment 7 upvotes 2 years ago

MaximusDurkimus shares experience with 0.25mg Finasteride, Minoxidil-induced lupus, and less than 10mg RU58841 for hair loss. Plans to try 0.025% topical Finasteride with 5% Stemoxydine and possibly Tretinoin, Fluridil, or CB-03-01 in the future.

community Starting DUT topical any tips ?

in Finasteride/Dutasteride 7 upvotes 10 months ago

The conversation is about using topical Dutasteride for hair loss. One tip given is to apply it to the scalp.

community Kintor Pharma Announces Completion of First Patient Enrollment in KX-826 Long-term Safety Phase III Trial for Treatment of AGA

in Research/Science 12 upvotes 1 year ago

Kintor Pharma has finished enrolling the first patient in a Phase III trial for KX-826, a treatment for androgenetic alopecia (AGA). One user has set a reminder to check back on the topic in a year.

community (20 M) 1 Year of Progress Fin and Min

in Progress Pictures 1232 upvotes 1 year ago

A 20-year-old man shared his one-year progress using finasteride and minoxidil for hair loss. He experienced no side effects, saw results within weeks, and despite occasional shedding, his hair grew back thicker and in previously bald spots.

community Before and After, 5 years apart. Topical minoxidil once daily and dutasteride 0,5 mg per day

in Finasteride/Dutasteride 188 upvotes 1 year ago

This conversation is about a user named Pregal1994 discussing their experience with hair loss and treatments of topical minoxidil once daily and dutasteride 0.5 mg per day over 5 years, leading to good results. Other users gave feedback on the photos, confirming that there was an improvement in the condition of the hair.

community Pyrilutamide PHASE 2 Results just one months to go. Are you excited???🤩

in Research/Science 97 upvotes 2 years ago

Pyrilutamide, a potential topical treatment for male pattern baldness, and the user's anticipation of its Phase 2 trial results. Several users discussed their experiences with Finasteride and RU58841, while others voiced skepticism about the efficacy of Pyrilutamide.

community Can someone from the group buy give an update on Pyrilutamide

in Research/Science 2 years ago

Pyrilutamide, a potential hair loss treatment that has been tested in Phase 2 trials and may be available for purchase through a group buy in June. It is purported to have similar effects on hair growth as Dutasteride.

community Something I wish I knew about hairloss 10 years ago

in Treatment 100 upvotes 1 week ago

Hair transplants can initially yield good results, but native hair is more reliable, and transplanted hair may still be lost over time. Early intervention with treatments like topical finasteride and minoxidil is recommended, but it's important to start with lower doses and manage expectations realistically.

community FINASTRIDE and switch to DUTASTRIDE, my experience

in Progress Pictures 135 upvotes 2 months ago

The user shared their experience with Finasteride and Dutasteride for hair loss. They initially had success with Finasteride but switched to Dutasteride after experiencing shedding, which continued, and are now considering a hair transplant.

community Aiming to Standardize RU58841

in Chat 7 upvotes 3 months ago

The conversation discusses the use of RU58841 for hair loss, focusing on its side effects, standardization issues, and user experiences. The user also inquires about the use of other treatments like minoxidil, finasteride, and microneedling.

community Everything you need to know about KX-826 product (pyrilutamide)

in Product 19 upvotes 3 months ago

The post and conversation discuss KX-826 (pyrilutamide) for hair loss treatment, with positive remarks about its advertising and authenticity in China. The user changed their perspective after further research and seeing genuine advertising.

community Is Anyone using Latanoprost at all?

in Product 9 upvotes 7 months ago

A user discusses using latanoprost, a costly treatment that may extend the hair growth phase and improve hair quality, wondering why it's not more popular. They already use a combination of finasteride and minoxidil and plan to incorporate latanoprost into their routine.

community i got more results 1 month 5 mg oral minoxidil and 1 mg dutasteride then i did 6 months on finasteride and topical minoxidil

in Finasteride/Dutasteride 49 upvotes 8 months ago

A user reported better hair regrowth with 5 mg oral minoxidil and 1 mg dutasteride than with finasteride and topical minoxidil, calling topical minoxidil a scam. Replies varied, with some defending topical minoxidil, questioning the user's application method, and suggesting that previous treatments might be contributing to the observed results.

community Anyone else crying themselves to sleep because of the pyrilutamide fail?

in Technology 43 upvotes 11 months ago

The conversation is about disappointment with pyrilutamide's performance as a hair loss treatment, with some users expressing interest in other treatments like Verteporfin, GT20029, and RU58841, while others suggest sticking with established treatments like finasteride or dutasteride.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 123 upvotes 11 months ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community Kintor has released an investor relations memo regarding Chinese Phase III trials for Pyrilutamide

in Update 53 upvotes 11 months ago

Kintor's Pyrilutamide (KX-826) showed hair growth in Chinese Phase III trials but did not significantly outperform placebo. The treatment was safe with no major adverse reactions reported.

community [10 months] Lookin Bout Halfway There👍👨‍🦲 — ru58841, dutasteride, minoxidil

in Progress Pictures 88 upvotes 1 year ago

The conclusion of the conversation is that the user "lemmeseesomeass" has experienced significant hair regrowth using a combination of RU58841, dutasteride, and minoxidil. They mention that RU58841 is effective but not medically approved. They provide instructions on how they use RU58841.

community Eliminating scalp itch leads to regrowth (and my RU58841 progress)

in Research/Science 61 upvotes 1 year ago

User experienced hair regrowth after eliminating scalp itch with RU58841. Others discussed itch and hair loss connection, and effectiveness of combining RU58841 with 5AR inhibitors.

community Fin/min/microneedling ~9 months – no results, actually worse

in Progress Pictures 96 upvotes 1 year ago

User harlital shared their 9-month hair loss journey using finasteride, minoxidil, and microneedling but experienced worse results. Commenters suggested patience, checking for other causes, and considering dutasteride after 12-24 months if no improvement.

community New Latanoprost-Based Formula Used by Hollywood Celebrities

in Treatment 25 upvotes 1 year ago

A new Latanoprost-based formula used by Hollywood celebrities to treat hair loss, with the formula containing minoxidil, tretinoin, melatonin, azelaic acid, zinc thymulin, vitamin B6, sandalore and methyl vanillate. It also mentions the potential of offering a combined sublingual minoxidil/oral dutasteride option in the future.