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    GlossaryPyrilutamide (pyril)

    topical treatment blocking androgen receptors to combat hair loss

    Pyrilutamide, also known as KX-826, is a topical non-steroidal anti-androgen being developed for the treatment of androgenetic alopecia (pattern hair loss). It works by blocking androgen receptors in hair follicles, which can help reduce hair loss and potentially promote hair regrowth.

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      community Pyrilutamide (KX-826) progress?

      in Is this regrowth?  11 upvotes 5 days ago
      The user has been using pyrilutamide 0.5% for over 7 weeks, alongside dutasteride, and noticed some hair improvement, particularly at the temples. They plan to continue and possibly try a 1% solution, with no shedding or side effects reported.

      community Pyrilutamide and RU alternatives?

      in Treatment  1 upvotes 3 weeks ago
      Pyrilutamide is officially available for purchase, and users suggest Fluridil as an alternative topical anti-androgen. Some users report positive results with pyrilutamide from Koshine.

      community Pyrilutamide ,the molecule’s true nature

      in Research  302 upvotes 2 months ago
      Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

      community Pyrilutamide just launched internationally, and all you're doing is hating

      in Product 2 months ago
      The post and conversation are about the high cost and skepticism surrounding pyrilutamide as a hair loss treatment, with comparisons to minoxidil, finasteride, and RU58841. The original poster defends pyrilutamide's effectiveness and criticizes others for dismissing it without proper understanding.

      community Pyrilutamide isn’t failed at all.

      in Technology  10 upvotes 4 months ago
      Kintor is producing a cosmetic with KX826, starting at 0.5% concentration and moving to 1%. The 0.5% concentration wasn't as effective as minoxidil and finasteride, but the 1% concentration shows promise.

      community Pyrilutamide stopping Minoxidil gains

      in Chat  2 upvotes 6 months ago
      Pyrilutamide is seen as effective for maintaining hair without regrowth, while Minoxidil is known for growing new hair but causes shedding of old hairs. There is a question if using Pyrilutamide would inhibit the hair regrowth effects of Minoxidil.

      community Best solution for pyrilutamide in UK?

      in Treatment 8 months ago
      The user is looking for a PG-free solvent in the UK or EU to make their own pyrilutamide solution for hair loss and is currently using finasteride, considering minoxidil. They hope pyrilutamide will help stabilize their hair loss.

      community PYRILUTAMIDE progress in 15 months

      in Progress Pictures  24 upvotes 9 months ago
      The conversation discusses hair loss treatments, specifically the progress made with Pyrilutamide over 15 months. One person suggests using oral Minoxidil or Dutasteride, but another mentions experiencing negative side effects from oral Finasteride.

      community Pyrilutamide Trial Phase 3 Results?

      in Research/Science  10 upvotes 10 months ago
      The conversation is about the release of Phase 3 trial results for pyrilutamide in China for treating hair loss. The user is inquiring if the actual results have been posted, noting that a recent release did not contain them.

      community Pyrilutamide phase III clinical trial results released

      in Research/Science  31 upvotes 11 months ago
      Pyrilutamide did not show effectiveness in regrowing hair compared to a placebo, but it may still help maintain existing hair by preventing DHT from causing follicle miniaturization. Some users believe it could be beneficial when used with other treatments like minoxidil, finasteride, and dutasteride.

      community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

      in Research/Science  122 upvotes 11 months ago
      The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

      community Pyrilutamide kintor pharmaceutical

      in Chat  6 upvotes 1 year ago
      The conversation is about seeking information on GT20029 from Kintor Pharmaceutical as a potential hair loss cure and inquiring about experiences with CosmeaRNA.

      community Pyrilutamide almost for 9 months

      in Progress Pictures  62 upvotes 1 year ago
      The user has been using pyrilutamide, topical finasteride, and 15% minoxidil for hair growth for almost 4 years. Despite mixed responses from others, the user reports seeing progress, especially with the addition of pyrilutamide, and plans to continue the regimen.

      community Pyrilutamide / KX-826 | Discussion EU

      in Research/Science  5 upvotes 1 year ago
      The conversation is about a user expressing concerns over the safety of a new drug called Pyrilutamide (also known as KX-826) for hair loss. The user will only trust the drug if it's permitted by EU regulations and sold by a reputable company.

      community A Technical Question About Pyrilutamide

      in Research/Science  5 upvotes 1 year ago
      Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

      community Pyrilutamide potential release date!

      in Update  9 upvotes 1 year ago
      The conversation discusses the potential release date of a hair loss treatment called Pyrilutamide. One user suggests it may be available in about 5 years.

      community Pyrilutamide 2 months update(with pics )

      in Is this regrowth?  27 upvotes 1 year ago
      The conversation discusses the effects of Pyrilutamide on hair growth after two months, with one person noting that while new hair regrowth isn't apparent, existing hair appears longer and thicker.

      community Pyrilutamide release in Europe?

      in Treatment  2 upvotes 1 year ago
      User asks about Pyrilutamide release in Europe, specifically Germany, and considers importing it from China. No specific treatments mentioned.

      community Pyrilutamide application questions

      in Treatment  3 upvotes 1 year ago
      Sprocketshead asks if pyrilutamide can be applied with minoxidil, and inquires about its consistency and odor. They want to know if it's more high maintenance than topical minoxidil.

      community Pyrilutamide for 16 weeks, with some progress

      in Progress Pictures  40 upvotes 1 year ago
      User gained hair with topical minoxidil and finasteride, then experienced shedding after starting pyrilutamide. After 12 weeks, new hairs grew and existing hairs thickened, hoping for more improvement in a year.
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