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Female with aga tried minoxidil 5% and spironolactone, no success yet. Gladyator96 suggests waiting 6 months, adding tretinoin or dermarolling with minoxidil.

Kintor Pharma has started a Phase II trial in China for GT20029, a potential new treatment for hair loss. Participants are discussing the significance, potential release dates, and comparing it to other treatments and technologies like stem cell hair transplants and SAMIRNA.

A user's experience with using Fin for hair loss, which includes shedding and regrowth, potential side effects, and the use of supplements, protein, and exercise as additional treatments.

Hair loss discussion mentions treatments like Finasteride, Dutasteride, and Minoxidil. Users share experiences, side effects, and advice on using these treatments.

Comparing the effectiveness of RU58841, Pyrilutamide and CB-03-01 as treatments for hair loss, with people discussing different aspects such as binding affinity, time of inhibition, safety data and cost.

The conversation discusses using homemade topical finasteride for hair loss, showing an increase in DHT levels despite treatment. The user applies 0.125mg daily, resulting in 113.4% of previous DHT levels.

A user's 3-month experience with pyrilutamide to reduce hair shedding, and how it may not be strong enough to stop the thinning of their hairline. Other users mentioned the effectiveness of minoxidil and finasteride for treating hair loss.

The potential effectiveness of topical dutasteride, as well as other hair loss treatments such as finasteride, RU58841, minoxidil, and various vitamins. Experiences from users who have used these treatments were shared.

A female user's experience with topical and oral finasteride for hair loss, which has been successful as evidenced by the reduction of miniaturized hairs. Replies to the post discussed the recommended dosage for females versus males.

A 104 year old man's impressive head of hair and speculations about how he has been able to maintain it; treatments such as minoxidil, finasteride, RU58841, dutasteride, 5-AR blockers, and other supplements are discussed.

Female with PCOS experiences receding and thinning hair, wants dutasteride instead of spironolactone. Discusses desire to reduce DHT without losing libido.

An update on the use of Pyrilutamide, a new drug for hair loss, which has resulted in no shedding or testicle ache; other users have questioned the science behind this and shared their own experiences with Finasteride, Minoxidil, and microneedling.

The conversation discusses the potential of a new hair loss treatment, GT20029, which targets androgen receptors in the scalp and is in phase 1 trials in China. Users express hope that this treatment will be more effective than current options like Minoxidil and Finasteride.

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

Ramsko1's experience with a hair loss regimen of oral minoxidil, dutasteride, ketoconazole cream, and dermarolling, which they started after considering taking their own life due to hair loss. Other users replied to offer support and ask questions about specific treatments.

Saw Palmetto is not effective for hair loss treatment and is not a recommended alternative to finasteride due to its inability to significantly inhibit DHT.

Long-term finasteride users report maintaining hair and experiencing regrowth, with some using it for over 20 years. Combining finasteride with minoxidil or hair transplants can improve results.

33 y/o male used topical fin/min and dermaroll biweekly, resulting in increased hair density and significant regrowth. He got the solution from Hims and also used a DermaPen for microneedling.

A user reported a significant reduction in DHT levels after 3 months of taking 1mg/day oral finasteride, along with using minoxidil foam, microneedling, and Nutrafol vitamins. They hope this will lead to hair growth and less shedding.

User shared progress in treating hair loss and improving skin, using treatments like finasteride, minoxidil, RU58841, tretinoin, microneedling, and skin care regimen. Others commented on the impressive results and asked about costs and side effects.

User reports 6-month progress using Fin, Min, Nizoral, and Dermaroll for hair loss. Others comment on visible improvement and suggest waiting up to 2 years for full effects.

A 57-year-old man with severe hair loss since age 14 tried various hair loss treatments over two years, including finasteride, dutasteride, minoxidil, and supplements, with some minor regrowth. He also experimented with topical treatments and microneedling, but results were not cosmetically significant.

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

The user experienced worse hair after removing a wig system and has been using Hairband 82 Comfort Flex, Hair Max supplements, dermarolling, and a scalp massager for 4 months without clear results. They are hesitant to use Minoxidil due to shedding concerns and avoid finasteride due to side effects, preferring Saw Palmetto instead.

A user has been taking finasteride for 7 months and is experiencing watery semen as the only side effect. They are considering taking zinc supplements to improve this condition.

The conversation is about the effects of grape seed extract on hair, with mixed experiences reported. One user advises against using it.

A user shared that adding Dutasteride to Finasteride worsened their hair loss, despite initial improvements with Finasteride alone. Others in the conversation debated the effectiveness of Dutasteride, with some suggesting individual responses vary and others defending its proven efficacy for hair loss.

The conversation discusses RU58841, a compound for hair loss treatment, which was found to be effective in a 6-month trial but was not pursued due to financial issues or marketability concerns, not safety. Some users are considering crowdfunding to release the research data, while others discuss personal experiences and safety concerns with RU58841.

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

The potential health risks associated with long-term use of finasteride and dutasteride, with some responses pointing out the low quality of the journal that published the review article as well as highlighting other alternatives such as keto or minoxidil, and RU58841.