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      community Can Micro Needling be harmful in long term?

      in Microneedling  10 upvotes 1 year ago
      The conversation discusses the use of microneedling for hair loss, with concerns about potential long-term effects like fibrosis and scarring. Users share experiences and opinions on combining microneedling with treatments like minoxidil and finasteride, but there is uncertainty about the long-term safety and efficacy.

      community Community ranking on what new drugs/studies we are most hopeful about?

       10 upvotes 2 months ago
      The conversation discusses potential hair loss treatments, including clascoterone, GT20029, ET-02, VDPHL01, and PP405, with hopes for new options by 2028. Current treatments like minoxidil and finasteride are expected to remain effective, with clascoterone and VDPHL01 as promising alternatives.

      community Why hasn’t anybody or any company done experiments on whether minoxidil and finasteride have effects on human collagen and elastin after a year of use compared to placebo? (In vivo not vitro)

       6 upvotes 7 months ago
      The conversation discusses the lack of in vivo studies on the effects of minoxidil and finasteride on human collagen and elastin after a year of use. It highlights the potential benefits of such research for understanding side effects and improving sales, despite challenges like cost and competition.

      community Potential ( but not yet confirmed ) pp405 leak through korean media.

       233 upvotes 10 months ago
      A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

      community Full extent of pp405 effectiveness

       14 upvotes 10 months ago
      The conversation discusses the potential effectiveness and future results of the hair loss treatment pp405, with questions about its impact on different hair loss stages and areas. There is anticipation for phase 3 trial results to provide more data, and hope that pp405 could enhance hair transplant outcomes.

      community Pp405 full presentation on new topical

       106 upvotes 5 months ago
      A new topical treatment, PP405, shows promising results for hair regrowth, potentially outperforming existing treatments like finasteride and minoxidil. However, it may still need to be combined with DHT blockers for optimal results, and its long-term effectiveness remains uncertain.

      community Is microneedling without min just cope?

       44 upvotes 2 months ago
      Microneedling alone is generally not effective for hair growth and is often combined with minoxidil for better results. Some users believe it helps with fibrosis and blood flow, but many see it as ineffective without additional treatments like minoxidil or finasteride.

      community I think microneedling before topical application of finasteride (or dut) is a path we should investigate (for those of us who don't care about systemic absorption). Here's why...

       20 upvotes 1 year ago
      Microneedling before applying topical finasteride or dutasteride may enhance their effectiveness by increasing local absorption in the scalp, despite concerns about systemic absorption. Users discuss combining this method with oral treatments and minoxidil, noting potential benefits and side effects.

      community So is this the actual trial results for pp405?????

       94 upvotes 5 months ago
      PP405 shows promising results for hair growth, potentially outperforming finasteride without side effects like erectile dysfunction. Users discuss using treatments like minoxidil, pyrilutamide, nizoral, and alfatradiol while waiting for PP405's availability.

      community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

       15 upvotes 5 months ago
      A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.

      community Reason why placebo group got regrow on trial phase 3

      in Chat  16 upvotes 2 years ago
      Placebo hair regrowth might be influenced by propylene glycol in lotions or participants lying about using other treatments like minoxidil, finasteride, or microneedling. Being part of a study can also improve hair health due to lifestyle changes.

      community Why is there no feedback on pge2/setipiprant?

       7 upvotes 9 years ago
      The conversation questions the lack of feedback on the effectiveness of PGE2 and setipiprant for hair loss, despite their availability. The user is puzzled by the absence of reviews or results, whether positive or negative.

      community Is this a start? Any difference at all?

      in Is this regrowth?  124 upvotes 1 year ago
      The user is using finasteride, minoxidil, and microneedling for hair regrowth and has noticed some improvement after nine weeks. They report no significant side effects and plan to continue the treatment to see further results.

      community Hyperbaric Oxygen Therapy (HBOT)

       7 upvotes 4 years ago
      Hyperbaric Oxygen Therapy (HBOT) is discussed as a potential treatment for androgenic alopecia due to its ability to reverse hypoxia and promote angiogenesis. The conversation explores its potential benefits for hair loss, though no studies have been conducted on this application yet.

      community Kintor has announced the results for their human Phase I trials of GT20029

       256 upvotes 3 years ago
      The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.

      community Has anyone had good results with Prof. Marliani's therapy?

       2 upvotes 11 months ago
      The conversation discusses hair loss treatments, specifically progesterone therapy with hydrocortisone butyrate, and the use of dutasteride and finasteride. Opinions vary on the effectiveness and side effects of these treatments, with some users advocating for acceptance of balding if treatments are not suitable.

      community Growth Stimulants that aren't Minoxidil...?

       7 upvotes 2 years ago
      The user is exploring hair growth stimulants other than Minoxidil, mentioning Stemoxydine, various peptides, drugs like Latanoprost and Bimatoprost, and natural remedies such as Rosemary Oil and Caffeine. They express concerns about the long-term effectiveness and safety of these alternatives and seek more information on viable options for hair regrowth.

      community Bloodwork after 3 months on finasteride

       3 upvotes 2 years ago
      The conversation discusses the effects of using finasteride, minoxidil, and Vitamin D supplements for hair loss, noting increased testosterone, high estrogen, bloating, and water retention. Users report improved hair thickness and libido, with some experiencing side effects like an itchy scalp.

      community New Hair Loss Treatment: Adipose Derived Secretomes

       18 upvotes 1 year ago
      Adipose-derived stem cell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.

      community Opinions on best microneedling protocol? Some thoughts...

       11 upvotes 3 years ago
      Microneedling can enhance hair growth by improving minoxidil absorption and stimulating blood flow. Users discuss optimal needle depths, with some favoring shallow frequent needling for better absorption and others preferring deeper needling for stem cell activation.

      community Latanoprost- an effective medication

       8 upvotes 7 months ago
      Latanoprost is discussed as a potential hair loss treatment, noted for its synergy with minoxidil and 5-AR inhibitors, but concerns include its effectiveness on scalp hair, cost, and potential skin darkening. Some users express interest in trying latanoprost or bimatoprost despite limited real-world evidence.

      community VDPHL01 phase-2/3 results comparison

      in Research/Science  128 upvotes 4 months ago
      The conversation discusses hair loss treatments, focusing on a new slow-release oral minoxidil compared to topical minoxidil and finasteride. The results show that twice-daily dosing of the new treatment is slightly more effective than once-daily, but concerns about cost, side effects, and the accuracy of reported results remain.

      community So what is the most compelling current research on a cure?

       4 upvotes 11 years ago
      Setipiprant, a PGD2 inhibitor, and RepliCel, a cell transplantation technology, are being explored as potential hair loss treatments. Current mainstream treatments like Minoxidil and Finasteride have limitations due to side effects and efficacy.

      community Oxytocin Pathway and Cinnamic Acid Research

       14 upvotes 2 years ago
      The conversation discusses the potential of cinnamic acid for hair growth. It also mentions treatments like Minoxidil, finasteride, and RU58841.