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      The story of RU58841/ PSK3841

      community The story of RU58841/ PSK3841

      in Research  622 upvotes 3 months ago
      RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community after several weeks of research, here's the stack I've decided on

      in Finasteride/Dutasteride  43 upvotes 3 months ago
      A 23-year-old experiencing diffuse hair thinning has chosen a treatment stack including topical finasteride, a blend of rosemary, peppermint, and pumpkin seed oils, procyanidine B2 spray, ketoconazole shampoo, and scalp massages. They avoid minoxidil due to family history of side effects and oral finasteride due to high estrogen levels.

      community blueprint is working so well it seems

      in Chat  537 upvotes 3 months ago
      The conversation discusses a person successfully using a combination of Minoxidil, finasteride, and other treatments for hair loss, resulting in significantly improved hair. Despite some criticism, many admire his dedication to health and anti-aging research.

      community 4-month Min - Diffuse thinking update

      in Progress Pictures  618 upvotes 4 months ago
      User shared a 4-month progress update on using minoxidil and 1.5 months on finasteride for hair loss. Reactions were mixed, with some expressing disbelief and others feeling inspired to start treatment.

      community No gains after 4 years of min and fin

      in Progress Pictures  92 upvotes 4 months ago
      User has seen no improvement after 4 years of using minoxidil and finasteride, and recently started dutasteride. Suggestions include adding oral minoxidil, microneedling, and considering a hair transplant.

      community Why is it "not right" to start off with Dutasteride?

      in Finasteride/Dutasteride  60 upvotes 4 months ago
      The conversation discusses whether it's better to start hair loss treatment with finasteride or dutasteride. Opinions vary, but many suggest starting with finasteride due to its shorter half-life and easier management of side effects, while others argue dutasteride is more effective and has fewer side effects.

      community Rosemary out here changing lives for the better

      in Treatment  90 upvotes 5 months ago
      Rosemary oil is being used as an addition to minoxidil and finasteride for hair health, with mixed opinions on its effectiveness. Some users report positive results, while others see no benefit or experience adverse effects.

      community about a year difference. i’m only 21 bruh

      in Progress Pictures  173 upvotes 5 months ago
      A 21-year-old user shared progress pictures showing hair loss treatment results after using finasteride for a year and minoxidil for 6-7 months. Despite some improvement, the user is unhappy with hair density and hairline.

      community This guy loses all transplanted hair?!

      in Transplants  160 upvotes 7 months ago
      A man lost his transplanted hair despite using minoxidil because he wasn't on a DHT blocker like finasteride, which is essential to prevent further hair loss. The conversation emphasizes that hair transplants are not a cure and require maintenance with medications to preserve results.

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 7 months ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  22 upvotes 8 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community June 2023 to Present. Finasteride only.

      in Progress Pictures  579 upvotes 9 months ago
      A man, 34, reports positive hair regrowth after using only Finasteride with no significant side effects, except possible weight gain. Users react with a mix of skepticism, congratulations, and requests for more details about his treatment and personal life.

      community My barber noticed my progress 😁

      in Update  208 upvotes 9 months ago
      A user's barber noticed significant improvement in their hair thickness after they started using 2.5mg Minoxidil since August 2023 and 1mg Finasteride daily since September 2023. The user has experienced some headaches when missing Minoxidil doses but has not noticed major side effects.

      community How uninformed the general public is about hair loss

      in Chat  313 upvotes 10 months ago
      The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

      community I just got back from the animal hospital and lost my cat

      in Minoxidil  475 upvotes 10 months ago
      A user shared a tragic experience where their cat died after being exposed to Minoxidil, warning others of its toxicity to pets. Some users discussed switching to oral hair loss treatments, while others expressed condolences and shared their own concerns and experiences with topical treatments around pets.

      community Is this true? Is long term taking fin harmful to the liver?

      in Chat  127 upvotes 10 months ago
      The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).

      community If RU58841 is such an effective anti androgen

      in Research/Science  48 upvotes 10 months ago
      RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

      community I am horny as hell due to fin.

      in Finasteride/Dutasteride  225 upvotes 10 months ago
      Some individuals taking finasteride for hair loss report increased libido and frequent masturbation, with no immediate hair regrowth but darker hair appearance. A dermatologist explains that finasteride may raise testosterone levels temporarily, which could lead to increased sex drive in some people.

      community Dutasteride 1 year regression. Depressing. (With pictures for proof)

      in Progress Pictures  14 upvotes 11 months ago
      A user shared their experience of hair loss progression after one year on dutasteride, expressing disappointment with no improvement and considering other treatments like RU58841. Other users offered mixed responses, some seeing no change, others suggesting the hair loss might have been worse without treatment, and discussing the role of testosterone and DHT in hair loss.

      community Does whey protein and creatine aggravate hair loss?

      in Research/Science  82 upvotes 11 months ago
      The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.