A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.
Hairloss treatments, specifically about the effectiveness of RU58841 compared to Pyrilutamide. Molecular weights and side effects were discussed in terms of efficacy and cost-effectiveness.
The conversation discusses a prescribed hairloss treatment combining 12.5% minoxidil with tretinoin, azelaic acid, and topical finasteride, costing $55 a month. One user criticizes the packaging for degrading tretinoin, another suggests it's an overpriced option and recommends topical dutasteride as an alternative due to its higher molecular weight and lower systemic absorption.
The conversation discusses natural DHT blockers like rice bran oil, which may reduce 5α-reductase activity similarly to Minoxidil and Dutasteride. One user argues that finasteride is more reliable and effective than natural alternatives.
The potential effectiveness of topical dutasteride, as well as other hairloss treatments such as finasteride, RU58841, minoxidil, and various vitamins. Experiences from users who have used these treatments were shared.
User is on vacation in Greece and wants to buy tretinoin or isotretinoin to improve Minoxidil absorption. They are considering isotretinoin since it is available over-the-counter in Greece but requires a prescription back home.
Hairloss discussion includes finasteride issues resolved by switching to dutasteride. Specific treatments mentioned: Minoxidil, Finasteride, and RU58841.
The conversation discusses hairloss and the ineffectiveness of a treatment called pyrilutamide, with one user experiencing negative results and questioning the product's authenticity.
Bryan Johnson uses topical dutasteride, minoxidil, and microneedling for hairloss. Users discuss treatment effectiveness and side effects, debating topical versus oral dutasteride efficacy.
The conversation is about using microneedling for hairloss treatment, including questions on disinfection and post-treatment care. The user mentions using oral minoxidil and finasteride, and considering dutasteride.
The user experiencing diffuse hairloss is using various treatments including RU58841, finasteride, minoxidil with tretinoin, anti-hairloss shampoo, and microneedling, and is considering adding peptides TB500, BPC157, and GHK-Cu. They have low growth hormone levels and are questioning its impact on hairloss, while another user suggests androgenic alopecia and androgens are likely the main cause ofhairloss.
The user experienced headaches and brain fog with a topical solution containing Dutasteride, Minoxidil, Tretinoin, Fluocinolone, Latanoprost, and Caffeine. They are considering switching to oral or topical Finasteride to see if it alleviates these side effects.
The user is exploring topical Saw Palmetto as a milder alternative to microdosing topical Finasteride for hairloss, aiming to minimize systemic DHT impact. They plan to experiment with this herbal remedy for a year to assess its effectiveness on their mild androgenetic alopecia without significant side effects.
Hairloss discussion includes finasteride intolerance and questioning if Pyrilutamide is an alternative. Pyrilutamide not commercially available, but may be tolerable if approved since it's not a 5aR inhibitor.
Combining Finasteride with topical Quercetin, Onion/Garlic juice and Peppermint Oil to reduce Wet Prostate Weight in Rats. Luke10191 asked the user LITUATUI to update them on progress after trying this combination of treatments for hairloss.
The effectiveness of Dutasteride compared to Finasteride in treating hairloss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.
User taking 1mg finasteride daily for 2 years, wants to block more scalp DHT. Seeks reference for additional topical DHT blockers like alfatradiol and fluridil.
A user shared their hairloss treatment which includes a custom solution with multiple ingredients, caffeine liquid, and saw palmetto, and mentioned shedding after 40 days of use. Some replies discuss the effectiveness and cost of the treatment, while others debate the usefulness of topical dutasteride.
The user has been using finasteride, minoxidil, and nizoral for hairloss but hasn't seen regrowth, only maintenance. They are considering switching to dutasteride, which is believed to be more effective, but are concerned about potential side effects.
The user experienced initial hair regrowth with topical dutasteride and minoxidil but later faced significant hair shedding, leading to doubts about the effectiveness of topical dutasteride. They plan to continue the treatment for a year and may switch to oral finasteride if no improvement is seen.
A user shared their successful hairloss and gray hair reversal routine, which includes Minoxidil, Cetirizine HCl, Latanoprost, Dutasteride, Melatonin, Caffeine, Tretinoin, Vitamin D3, and Vitamin E. They also use a red light cap, oral Minoxidil, and are developing new treatments.
Topical dutasteride is suggested as a low side-effect treatment for hairloss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.
Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.
Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.
A 24-year-old male has been using 0.1% finasteride and 5% minoxidil daily for four months, added dermarolling and topical dutasteride, and sees hair regrowth, improving from a Norwood scale 4a to 3a. He wants to optimize his hairloss treatment routine.