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      community Ruxolitinib - Start of a case study

      in Research/Science  10 upvotes 8 months ago
      The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

      community Why do some have no change even on nuclear stacks ?

      in Research/Science  16 upvotes 11 months ago
      Some people see significant hair regrowth using treatments like finasteride and minoxidil, while others experience little to no improvement even with comprehensive treatment plans. Factors such as individual sensitivity to DHT may influence the effectiveness of these hair loss treatments.

      community Potential Cure?! Verteporfin- unlimited HT

      in Research/Science  44 upvotes 1 year ago
      The conversation discusses verteporfin as a potential treatment for hair regeneration, which could lead to unlimited hair transplants by healing the donor area. Some users are considering using verteporfin now, while others are hopeful it will be available for future hair transplants.

      community important questions about RU58841

      in Research/Science  3 upvotes 1 year ago
      The user has been using finasteride for hair loss and is considering adding RU58841. They ask about RU58841's effectiveness, potential heart side effects, duration of action, dosage increase over time, transitioning to GT20029, and where to find the liquid form.

      community AnagenInc says GT20029 is possible now

      in Research/Science  117 upvotes 1 year ago
      AnagenInc is ready to produce a hair loss treatment called GT20029 if there is enough demand. People are discussing combining it with other treatments like finasteride and minoxidil, and some are concerned about the legitimacy and safety of gray market products.

      community Methods Of Staying Safe On Ru58841 - My 2 Cents

      in Research/Science  12 upvotes 4 weeks ago
      RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

      community Spironolactone topically with a try ?!

      in Research/Science  1 upvotes 11 months ago
      A 30-year-old male is considering using dutasteride and fluridil for hair loss maintenance and is curious about the effectiveness of topical spironolactone, as he cannot take finasteride. He is also planning a hair transplant.

      community A Technical Question About Pyrilutamide

      in Research/Science  5 upvotes 1 year ago
      Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

      community Who said GT20029 would be applied only few times per month?

      in Research/Science  10 upvotes 2 years ago
      The conversation discusses the safety and effectiveness of a hair loss drug, GT20029, and the possibility of infrequent application, with users hoping for once-daily use and speculating on the drug's duration of effect on the scalp. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

      community PYRILUTAMIDE KX-826 experience

      in Research/Science  99 upvotes 2 years ago
      A user's experience with the hair loss treatment Pyrilutamide KX-826, which has resulted in some side effects and shedding. The conversation also includes advice for baseline pictures and trying treatments for at least 6 months.

      community Topical melatonin/oral

      in Research/Science  12 upvotes 3 years ago
      The conversation discusses the potential positive effects of melatonin on hair growth. The original poster plans to try both oral and topical melatonin and is seeking recommendations for a good source.

      community Logging myself monthly for dut 0.5 mg and min5mg oral

      in Research/Science  13 upvotes 1 month ago
      The user is documenting their experience with oral dutasteride (dut) 0.5 mg and minoxidil (min) 5 mg for hair loss, planning to add RU58841 after three months. They previously used finasteride with success and are now experiencing increased shedding but also new hair growth.

      community hairloss in my 20s has ruined my life.

      in Research/Science  373 upvotes 3 months ago
      A person in their 20s is struggling with hair loss, using treatments like minoxidil and finasteride. Suggestions include self-improvement, therapy, hair transplants, and focusing on acceptance and confidence.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 3 months ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community Hair loss 30F - thoughts on red light therapy vs min/fin?

      in Female  6 upvotes 4 months ago
      The conversation discusses hair loss treatments for a 30-year-old female, comparing red light therapy with minoxidil and finasteride. Concerns about hormonal impact and potential pregnancy are raised, with suggestions to consider spironolactone and microneedling, while emphasizing the importance of consulting a dermatologist.

      community Why are there no FDA approved NSAA's yet?

      in Research/Science 8 months ago
      The conversation discusses why there are no FDA-approved NSAAs like RU58841 on the market, despite their potential superiority to 5AR inhibitors like finasteride. It explores the effectiveness of treatments like Minoxidil, finasteride, and RU58841 for hair loss.

      community Is pyrilutamide safe to use or still unknown?

      in Research/Science  12 upvotes 2 years ago
      The conversation is about the safety and effects of using pyrilutamide for hair loss. One person reported severe negative effects, another experienced minor side effects without much benefit for hair, and a third found the anecdote helpful in making a decision.