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      community Mechanism of action of alfatradiol (17 alpha estradiol)

      in Research/Science  6 upvotes 5 months ago
      The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

      community Is Topical Dutasteride best for preventative loss?

      in Finasteride/Dutasteride  7 upvotes 1 year ago
      The user is considering using topical dutasteride to prevent hair loss progression from Norwood 1 to Norwood 2 at age 25, and is concerned about the long-term effectiveness and potential shedding from the treatment. They are currently using a shampoo with caffeine, rosemary, and saw palmetto, and have noticed hair thinning and changes since age 20.

      community What's your option on complementary treatment

      in Product  3 upvotes 5 months ago
      The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

      community Father has decent amount of hair but im balding ?

      in Chat  15 upvotes 10 months ago
      A user is concerned about male pattern baldness despite their father having hair. Replies suggest visiting a dermatologist and considering finasteride or dutasteride, as natural methods are ineffective.

      community Genetics are so weird and unpredictable

      in Minoxidil  111 upvotes 1 week ago
      The user experienced male pattern baldness starting at 18, tried finasteride with no success, and switched to dutasteride, which halted hair loss. Minoxidil had no effect for them, while their brother, who didn't use AR inhibitors, maintained a juvenile hairline and successfully grew a beard with minoxidil, highlighting the unpredictable nature of genetics in hair loss and treatment response.

      community How to know if shedding is from tren or minoxidil?

      in Minoxidil  5 upvotes 7 months ago
      The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

      community 48 Days Fin, Min, and Derm Part 2

      in Progress Pictures  264 upvotes 1 year ago
      The user discussed their positive experience with hair loss treatments Finasteride, Minoxidil, and Dermarolling, showing significant progress in 48 days. Other users expressed interest in trying these treatments, asked about side effects, and one noted that they've observed good results in black people.

      community I think I’m on to something

       23 upvotes 5 years ago
      The user shared their personal experience with hair loss, hormone imbalances, and treatments including testosterone boosters, natural estrogen blockers, and DHEA. They suggest that low-dose finasteride and natural hormone therapy could reduce hair loss with fewer side effects.

      community find a cure for this shit already

      in Chat  207 upvotes 4 years ago
      Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  10 upvotes 4 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community 22 years since the last major development

      in Technology  51 upvotes 3 years ago
      The conversation discusses the lack of significant advancements in hair loss treatments since the introduction of finasteride 22 years ago, with many expressing frustration over the failure of new projects and skepticism about future developments. Some users mention hair transplants and other potential alternatives like Alfatradiol and Fluridil, but acknowledge finasteride's dominance in the market due to its effectiveness and affordability.

      community Watching my younger brother bald hurts so much.

      in Treatment  261 upvotes 3 months ago
      A 19-year-old is distressed about his 17-year-old autistic brother's hair loss, projecting his own insecurities despite being on finasteride and dutasteride. Replies suggest the brother might not care about balding, and the poster should address his own issues.

      community Platelet rich plasma treatment

      in Treatment  5 upvotes 7 months ago
      A 27-year-old male experienced rapid hair loss after dengue fever, which activated a balding gene. The doctor suggested platelet-rich plasma treatment for hair regrowth.

      community How soon is hair clone? Next five years?!

      in Research/Science  15 upvotes 5 months ago
      Hair cloning is humorously discussed as always being 5-7 years away, with skepticism about its near-term availability. Gene editing to reactivate dormant follicles is suggested as a more likely solution within the next ten years.

      community CRISPR treatment for AGA on the horizon after approval for blood disorders

      in Treatment  9 upvotes 9 months ago
      CRISPR treatments for blood disorders have been approved, leading to discussions about its potential for treating hair loss (AGA). A study showed that editing a gene related to DHT sensitivity could lead to hair regrowth, suggesting CRISPR may eventually be used for AGA, but it's expected to be expensive and not soon available.

      community I want to sacrifice my hair in the name of science

      in Chat  12 upvotes 1 year ago
      The conversation discusses various theories of hair loss, including DHT sensitivity and genetic factors, with the user willing to use themselves for research due to having a hair loss gene but different hair loss patterns compared to their brothers. Specific treatments were not mentioned in the provided text.

      community When are we getting a cure to hair loss?

      in Chat 1 year ago
      Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

      community Silicon Valley backed company aims to cure hair loss

      in Technology  51 upvotes 2 years ago
      A Silicon Valley-backed company aims to cure hair loss. Exciting advancements include mRNA therapies, gene editing, hair cloning, AR degraders, anti-androgens, cell-based rejuvenation, and AI-based drug discovery, with hopes for FDA approval of GT20029 within 10 years.

      community 3 months progress!! Fin + Min + Derma roller + Nizoral Shampoo.

      in Progress Pictures  567 upvotes 1 year ago
      The post discusses a user's successful hair regrowth after 3 months using 1 mg oral finasteride, oral minoxidil, weekly 1.5mm derma rolling, and Nizoral shampoo every other day, with no side effects. The conversation includes various responses, questions about the user's ethnicity and previous scalp condition, and suggestions for topical treatments.

      community Difference: GT20029 vs CosmeRNA

      in Treatment  9 upvotes 1 year ago
      GT20029 and CosmeRNA are both potential hair loss treatments; GT20029 breaks down the androgen receptor, while CosmeRNA prevents its production. Continuous use is needed, but less frequently than current treatments like Minoxidil and Finasteride.