The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.
This user discussed their hair loss journey and shared pictures to get advice on the best treatment option. They had been using finasteride since November 2020, with a minimal amount of ground lost, and recently added minoxidil in April 2021. A transplant was suggested as an option, although they have not made a decision yet.
A user jokes about their 2-year-old son having their hairline and asks if it's too late for finasteride. Replies include humorous suggestions like growing a beard, working out, and hair transplants.
Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.