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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Diffuse thinning is the worst man

      in Chat  248 upvotes 10 months ago
      The conversation is about the struggles of dealing with diffuse thinning at a young age and the lack of significant improvement after using treatments like finasteride and minoxidil. Some suggest additional methods like derma rolling, microneedling, and hair fibers, while others share their own experiences and encourage persistence with treatment.

      community Atherosclerosis as cause of balding and treatment

      in Treatment  61 upvotes 1 year ago
      Hair loss may be caused by calcification of capillaries in the scalp, restricting blood flow to hair follicles. A daily treatment regimen including high doses of Vitamins D and K, Magnesium, and Nattokinase could potentially decalcify these capillaries, improving blood flow and hair growth. However, some users warn against excessive Vitamin D intake and emphasize the need for medical consultation.

      community Achievement Unlocked: Regrow Hairline

      in Progress Pictures  270 upvotes 2 years ago
      FluffyyKoala shared their 6-month hair regrowth journey using finasteride, minoxidil, and microneedling, with positive results and minimal side effects. Others in the conversation shared their experiences, asked questions, and congratulated FluffyyKoala on their progress.

      community Losing hair everywhere, idk what to do :(

       29 upvotes 5 years ago
      A 22-year-old male has been experiencing widespread hair loss for over four years, including pain and significant shedding. Treatments tried include ketoconazole shampoo, fluocinonide topical solution, biotin, ACV, and dry shampoo, but none have been effective.

      community Buzzed my hair again to see where I’m really at, nothing has really changed in the front but I think the mid-scalp anterior mid-scalp vertex and crown diffusing has stopped/reversed completely. gonna grow it out again, I’m about 7.5 months in now.

       130 upvotes 6 years ago
      Hair loss treatments, particularly using finasteride and minoxidil. The user has experienced positive results from taking finasteride with no side effects and suggests listening to the podcast of Spencer Kobren for more information on such treatments.

      community 7 Week Progress Pic or am I tripping?

      in Is this regrowth?  22 upvotes 1 month ago
      A 40-year-old using 1mg finasteride daily reports noticeable hair regrowth in 7 weeks and plans to start 5% minoxidil and microneedling. Feedback is mixed, with some seeing progress and others suggesting a hair transplant.

      community 7 months progress. fin 1.25 mg, oral min 2.5 mg, keto shampoo, micro-needling once per month. M/32

      in Progress Pictures  82 upvotes 7 months ago
      A user shared a 7-month hair loss treatment progress using finasteride 1.25 mg, oral minoxidil 2.5 mg, ketoconazole shampoo, and monthly micro-needling, noting denser hair and improved quality but no significant regrowth. They experienced mild testicular discomfort and heart palpitations, considering switching to topical minoxidil to avoid side effects.

      community Using Minoxidil without Finasteride

      in Minoxidil 1 year ago
      The effectiveness of using minoxidil alone as a hair loss treatment, and whether or not finasteride should be taken in addition to the minoxidil. Replies suggest that minoxidil is only effective for a short period of time, and finasteride should be added to the treatment plan.

      community God bless H&M's fitting room lighting

      in Chat  197 upvotes 3 years ago
      Diffuse thinners find shopping challenging due to harsh overhead lighting, but H&M's side lighting in fitting rooms is more flattering. Many users humorously suggest banning overhead lighting to improve the shopping experience.

      community 10 month update! Fin/min/dermaroller/niz

       446 upvotes 5 years ago
      A 10 month update on the effectiveness of a hair loss treatment regimen involving minoxidil, finasteride, dermarolling and nizoral. Questions were asked about using minoxidil alone, dermaroller length, age, and when results were seen.

      community Why do some have no change even on nuclear stacks ?

      in Research/Science  16 upvotes 9 months ago
      Some people see significant hair regrowth using treatments like finasteride and minoxidil, while others experience little to no improvement even with comprehensive treatment plans. Factors such as individual sensitivity to DHT may influence the effectiveness of these hair loss treatments.

      community I wish I'd kept on treatment 4 years earlier...

      in Chat  28 upvotes 11 months ago
      The user regrets not continuing hair loss treatment with finasteride earlier and plans to restart it along with minoxidil. Another user suggests trying dutasteride and oral minoxidil as a more effective treatment.

      community Losing gains from 7 months of oral min, fin, dut.

      in Update  66 upvotes 11 months ago
      A user reported losing hair after 7 months of using oral minoxidil, finasteride, and dutasteride, but others reassured that this is likely just a shedding phase where old hairs fall out to make way for new growth. Some users experience sheds every 7-8 months and suggest staying consistent with treatment.

      community This and ketoconazole 2% life changing

      in Ketoconazole  69 upvotes 1 year ago
      The post discusses the user's experience with hair loss treatment using finasteride, clobetasol propionate, and ketoconazole shampoo. The conversation warns about the potential side effects of clobetasol, a powerful topical steroid, and emphasizes its short-term usage.

      community "DHT Itch" and onset Seborrheic Dermatitis

      in Research/Science  76 upvotes 1 year ago
      The post and conversation discuss the link between DHT (a hormone), scalp itchiness, and hair loss. Some users share their experiences and treatments, including the use of fluconazole, corticosteroids, and ketoconazole shampoo, with one user suspecting minoxidil as a potential cause of their symptoms.

      community Stop Lurking and Start Treatment NOW

      in Chat  62 upvotes 2 years ago
      Start hair loss treatment as soon as you notice thinning to prevent further loss; finasteride and minoxidil are suggested treatments, with the option to switch to topical treatments if side effects occur. Some regret not starting treatment earlier, and maintaining current hair is more likely than regrowth.

      community Small personal success with fin and microneedling

      in Chat  29 upvotes 4 years ago
      A 29-year-old man experienced significant hair thickening at the front and top after using finasteride and microneedling for two months, as noticed by his hairdresser. He used 0.5 mg/day of finasteride orally, switched to a topical solution, and performed microneedling with a Derminator2 every 6-7 days.