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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 4 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community 11 months on fin + min. Thoughts?

      in Progress Pictures  916 upvotes 4 months ago
      A user shared progress pictures after 11 months on finasteride and minoxidil, with intermittent microneedling. The community responded positively, noting significant hair regrowth and encouraging continued treatment.

      community Minoxidil For 2 Years, What is this?

      in Treatment  111 upvotes 4 months ago
      The user has experienced significant hair thinning despite using 2.5 mg minoxidil for 2 years. Other users suggest adding finasteride or dutasteride and consulting a dermatologist for a proper diagnosis.

      community Topical Dutasteride. Does it work?

      in Finasteride/Dutasteride  13 upvotes 6 months ago
      Topical dutasteride may be effective for hair loss by staying in the scalp and minimizing bloodstream absorption, potentially improving hair results and reducing side effects. The user seeks advice on its effectiveness.

      community Reasons why Topical worked but Oral Minoxidil didn’t?

      in Minoxidil  16 upvotes 9 months ago
      Some people find topical minoxidil effective for hair loss, but oral minoxidil doesn't work for them, possibly due to absorption issues. Others have had better results with oral minoxidil, suggesting individual responses vary.

      community What an amazing time to be alive

      in Finasteride/Dutasteride  183 upvotes 1 year ago
      The post discusses a user's experience with hair loss treatments, specifically topical finasteride, minoxidil, and micro-needling, and their plan to switch to oral versions and add Dutasteride. The conversation includes various responses, with some users sharing their own experiences and side effects, and others expressing desire for a more permanent hair loss solution.

      community 1mg FIN only. 1 year progress on (28M)

      in Progress Pictures  344 upvotes 1 year ago
      The user "Bardo95" shared their one-year progress using finasteride (FIN) for hair loss. They experienced thickening of their general thinning and received compliments on their progress. Other users discussed their own experiences with finasteride and expressed hope for similar results.

      community 3 months fin, min, dermarolling

      in Progress Pictures  182 upvotes 1 year ago
      The post is about a user's progress with using finasteride, minoxidil, and dermarolling for hair loss. The conversation includes comments about different treatments and methods used.

      community My barber is seriously making me lose hope

      in Minoxidil 2 years ago
      This conversation is about a user struggling with hair loss who has been told by their barber that minoxidil does not work and the only solution is to accept it. Other users have encouraged them to continue using finasteride and minoxidil, as well as look for another barber, since these treatments are scientifically proven to be effective in combating hair loss.

      community Homemade topical spironolactone

      in Research/Science  26 upvotes 2 years ago
      The potential effectiveness of homemade topical spironolactone in treating hair loss, with studies suggesting it is more effective than finasteride and even minoxidil when used as monotherapy. The conversation also mentions that other anti-androgens are being developed which may soon hit the market.

      community Guide: How to EASILY get prescription oral minoxidil

      in Minoxidil  21 upvotes 2 years ago
      The conversation provides a six-step guide on how to get a prescription for oral minoxidil (OM) for hair loss by finding a supportive dermatologist, even if they are not local, and preparing a case for its use during a virtual consultation. The guide emphasizes the importance of research, insurance considerations, and the potential for initial hair shedding with OM treatment.

      community Bad experience at Dermatologist

      in Update  41 upvotes 2 years ago
      A user had a disappointing dermatologist appointment where they were denied prescriptions for Dutasteride and oral Minoxidil for hair loss and were only offered a hair transplant referral. Other users sympathized, discussed self-medication, and suggested consulting a transplant doctor for up-to-date treatments.

      community Four Months on Zix - Before and After Pictures

      in Treatment  7 upvotes 3 years ago
      The user shared their positive experience using Zix and Rogaine foam for hair regrowth, noting new thick hairs and no side effects. They plan to continue and refine their regimen for better results.

      community Listen to anyone besides your Mom while fighting hair-loss

      in Satire  464 upvotes 4 years ago
      Hair loss treatments, with people sharing their experiences of trying to get help from family members and how genetics can affect the severity of hair loss. Treatments mentioned include finasteride, minoxidil, RU58841, scalp massage, whey protein and bleaching.

      community A Different Take on Curing MBP

       16 upvotes 5 years ago
      Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

      community Help in Germany to get recommended medicine

      in Finasteride/Dutasteride  5 upvotes 4 months ago
      A user in Germany is seeking advice on obtaining Dutasteride, Minoxidil, and Biotin for hair treatment before a hair transplant. They face difficulties getting prescriptions and are concerned about delays due to required exams.

      community Pérdida de cabello en jóvenes (15-20 años) mi experiencia.

      in Treatment  20 upvotes 4 months ago
      A 19-year-old shares his hair loss experience and treatment routine, which includes 1mg finasteride daily, 2mg oral minoxidil daily, ketoconazole shampoo every 2 days, and a healthy lifestyle. He notes that oral minoxidil is showing better results than topical minoxidil.

      community Do you see any progress? 9 months in.

      in Progress Pictures  79 upvotes 1 year ago
      The user has been using minoxidil, dutasteride, and mesotherapy for hair loss for 9 months and recently added a derma-roller to their routine. Commenters agree there is visible progress and improvement in hair thickness.

      community Feels bad man reading some of this posts

      in Treatment  31 upvotes 2 years ago
      Obtaining treatments for hair loss, such as Finasteride and Minoxidil, without a prescription in some European countries. Replies to the post included experiences of being able to obtain treatments through pharmacies without prescriptions.

      community How do people afford finasteride/dutasteride?

      in Treatment  27 upvotes 6 months ago
      People discuss the high cost of brand name finasteride and dutasteride, suggesting generics as cheaper alternatives. They share prices from various regions, highlighting significant cost differences.

      community 2 and a half years progress and update

      in Progress Pictures  315 upvotes 1 year ago
      After 2.5 years of using 1mg finasteride daily, 5% minoxidil foam twice daily, and weekly micro-needling, the user reports thicker, healthier hair without further loss. They noticed initial regrowth at 3 months, with significant improvement up to 18 months, and no negative side effects from the treatment.