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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 2 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community 3 month update: fin/min and derma stamp .5

      in Finasteride/Dutasteride  262 upvotes 3 months ago
      The user reported using 1.1 mg finasteride, 5 mg minoxidil, 1 mg biotin, dermastamping twice a week, and Nizoral shampoo and anti-itch liquid. The replies praised the progress and suggested a follow-up at six months.

      community Verteporfin and Microneedling

      in Treatments 4 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community 4 month progress (delayed start)

      in Progress Pictures  765 upvotes 7 months ago
      The user has been using Minoxidil for 3.5 months, Finasteride for 3 months, derma rolling twice a week, taking Saw Palmetto daily, and using Rosemary Shampoo to treat hair loss, and is happy with the progress despite some remaining hair loss at one temple. They encourage others to start treatment early if hair loss affects their confidence, and they use a 5% Minoxidil solution and take 2.5mg of Finasteride three times a week.

      community My experience with 2 years of fin + min after ht

      in Progress Pictures  13 upvotes 7 months ago
      A 31-year-old man shared his 2-year experience using finasteride and minoxidil after a hair transplant on the front and mid scalp, noting improvement but still having a thin crown. He recently started dermastamping, plans to use ketoconazole shampoo, and uses hair fibers for extra confidence at events.

      community How are you using topical melatonin?

      in Treatment  1 upvotes 7 months ago
      The user is experimenting with topical melatonin for hair loss by dissolving melatonin tablets in a solution, but is having trouble with dissolution and is curious about others' methods of application and any effects on energy levels. They mention considering mixing with minoxidil but have not done so, and suggest that melatonin is best used at night.

      community 6 months into Dutasteride and my hair is way worse than before

      in Finasteride/Dutasteride  72 upvotes 7 months ago
      After six months on Dutasteride, the user's hair is worse than before, despite previously trying finasteride and RU/Fluridil without success. Some suggest continuing Dutasteride and adding progress photos, while others share their positive experiences or advise sticking to one treatment for at least a year.

      community Our Follicles, who art in hairven, hallowed be thy name; thy hairdom come; thy will be done; on earth as it is in hairven. Give us this day our daily regrowth. And forgive us our hat usage, as we forgive those who own hair against us. And lead us not into transplantation; but deliver us from balding

      in Progress Pictures  42 upvotes 7 months ago
      A 21-year-old with accelerated hair loss due to stress and weight loss is using minoxidil, finasteride, and microneedling to combat balding, despite experiencing a significant initial hair shed. They are committed to continuing treatment for at least three months and are considering switching to topical finasteride if necessary.

      community Probably progress in about 4 months

      in Progress Pictures  47 upvotes 8 months ago
      The user started using minoxidil and finasteride for hair loss but stopped minoxidil due to scalp issues and tinnitus. They experienced testicular pain, shedding, and side effects like itchy chest and watery sperm, but noticed considerable hair regrowth except at the temples.

      community 1yr of treatment 40yr old min/dut/ru/needling

      in Progress Pictures  353 upvotes 8 months ago
      A 40-year-old used minoxidil, dutasteride, RU58841, and microneedling for one year, resulting in noticeable hair regrowth despite initial shedding. They believe having more hair is beneficial for dating at their age and also recommend staying fit, eating well, and sleeping over 8 hours.

      community 2 month difference before (first 4 photos) vs after

      in Progress Pictures  19 upvotes 8 months ago
      A 16-year-old has been using microneedling, rosemary oil, coconut oil and egg mask, Nizoral shampoo, saw palmetto, and supplements for hair loss and is asking if there's progress. It's suggested to replace some oils with minoxidil, continue saw palmetto, and possibly start finasteride at 18.

      community Finasteride 1.25mg 10 month Progress

      in Progress Pictures  149 upvotes 8 months ago
      The user shared a 10-month hair loss treatment routine using Finasteride, ketoconazole shampoo, and Red Light Therapy, noting significant progress and considering adding Dutasteride. They experienced initial side effects and changes in libido, but overall reduced hair shedding and regrowth, especially at the temples.

      community 1 month Hims oral fin (1.1 mg) and min (3 mg)

      in Progress Pictures  31 upvotes 9 months ago
      The user shared a 1-month progress picture showing improvement in hair thickness and new growth after using Hims oral finasteride (1.1 mg) and minoxidil (3 mg), with no side effects, and also mentioned using ketoconazole shampoo and a rosemary hair mask. They plan to post updates at 6 and 12 months.

      community 6 months of Mexican Finasteride (1.25mg every other day). It’s working slow but steady.

      in Progress Pictures  280 upvotes 10 months ago
      A user shared a 6-month hair loss treatment routine including Mexican finasteride (1.25mg every other day), daily minoxidil, bi-weekly dermarolling, and ketoconazole shampoo twice a week, noting significant crown growth and some frontal hairline improvement with initial side effects that have since subsided. They are seeking advice to improve results, particularly at the frontal hairline, without resorting to a hair transplant.

      community 2 and a half years progress and update

      in Progress Pictures  319 upvotes 11 months ago
      After 2.5 years of using 1mg finasteride daily, 5% minoxidil foam twice daily, and weekly micro-needling, the user reports thicker, healthier hair without further loss. They noticed initial regrowth at 3 months, with significant improvement up to 18 months, and no negative side effects from the treatment.

      community 4 months M26 Fin/Min/Keto/microneedle

      in Progress Pictures  39 upvotes 11 months ago
      A 26-year-old male shared progress pictures after 4 months of treating hair loss with finasteride (1.25 mg on Mondays, Wednesdays, and Fridays), topical minoxidil twice daily, ketoconazole shampoo twice weekly, and weekly microneedling at 1.5 mm. He is seeing hair growth improvement, especially in the front, and is considering hair grafts for the crown area if necessary for more density.

      community 13 month dutasteride update. Still improving.

      in Progress Pictures  34 upvotes 1 year ago
      The user switched from finasteride to dutasteride for hair loss treatment, also using topical minoxidil, micro needling, keto shampoo, and PRP sessions. They've seen improvements, with reduced hair shedding and new hair growth, especially at the hairline.

      community Nest topical compound stack to fight hair loss

      in Treatment  1 upvotes 1 year ago
      The user is seeking advice for the best topical treatment to combat their ongoing hair loss, despite already using oral dutasteride, RU-58841, and minoxidil. They are considering adding CB-03-01 or topical Spiro to their regimen to lower testosterone levels at the follicles.

      community Opinions on current hair loss stack and recommendations for HT?

      in Progress Pictures  8 upvotes 1 year ago
      A 24-year-old man is seeking advice on his current hair loss treatment, which includes 0.5mg Dutasteride daily, 2.5 mg oral Minoxidil daily, and daily low-level light laser therapy, as he's not seen improvement recently. He's also considering a hair transplant in South Korea at age 25 and is asking for opinions on this plan.

      community Can someone explain the Dutasteride hysteria in this community?

      in Finasteride/Dutasteride  58 upvotes 1 year ago
      The conversation is about the double standard in the hair loss community regarding shedding when using different treatments. The conclusion is that shedding is considered normal when starting finasteride or minoxidil, but not when starting dutasteride, despite the fact that dutasteride is more effective at reducing DHT.

      community 6 months After hair transplant in turkey.

      in Progress Pictures  22 upvotes 1 year ago
      A user shared their positive experience with a hair transplant in Turkey, where they received 3500 grafts. They started using finasteride, minoxidil, biotin, and ajuga reptans supplements after one month, and posted progress pictures at 1, 2, and 6 months post-transplant.

      community So Pyrilutamide has been postponed by one year. How likely is that to happen to GT20029

      in Treatment  27 upvotes 1 year ago
      The conversation discusses the delay in the release of a new hair loss treatment, Pyrilutamide, and speculates on potential safety concerns as a reason for the delay. It also mentions GT20029 as another future treatment option, with a release at least five years away, and touches on the avoidance of research chemicals due to uncertainty about their authenticity.

      community 1 year and 3 months on Finasteride. No side effects.

      in Progress Pictures 1 year ago
      A user happy with their 1 year and 3 months of finasteride use with no side effects, which has resulted in recovery of their hairline. Other users have responded with congratulations, questions, and caution against using the medication at such a young age.

      community Result after 8 months on minoxidil and finasteride.

      in Progress Pictures  71 upvotes 1 year ago
      The user shared progress pictures showing hair growth after 8 months of treatment with 5% minoxidil twice daily, 1 mg finasteride once daily, head massages, omega 3, vitamin D, zinc, and using a dermaroller starting at the 6th month. They are satisfied with the results and experienced no side effects.

      community hairline resurrection — 2 months before/after [5mg oral minoxidil, 1mg finasteride everyday, 2% keto shampoo every three days, weekly 0.5mm dermarolling]

      in Progress Pictures  484 upvotes 1 year ago
      This conversation was about a user named Substantial_Pen_1099 who has been using an regimen of 5mg oral minoxidil, 1mg finasteride everyday, 2% keto shampoo every three days, and weekly 0.5mm dermarolling for hair loss treatment over the course of 3 months. Others in the conversation expressed disbelief at their progress, to which Substantial_Pen_1099 provided video proof as evidence.