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      community bro where tf is GT20029, Q1 2024 is over already

      in Research/Science  42 upvotes 6 months ago
      The conversation discusses the delay in the release of GT20029 for hair loss treatment and skepticism about its effectiveness. Participants mention other treatments like verteporfin and advancements in transplant procedures as more realistic options.

      community 1 year on fin. Take the pill. NOW.

      in Progress Pictures  353 upvotes 6 months ago
      After one year on finasteride, a user reports positive hair regrowth and minimal side effects, encouraging others to try the treatment despite potential risks. Other users share varied experiences with finasteride, some seeing improvements and others still waiting for results.

      community Kintor does not have abandoned KX-826 - ANNUAL RESULTS 2023

      in Product  8 upvotes 7 months ago
      The conversation discusses disappointment with the hair loss treatment KX-826 but notes that the company Kintor is still focused on developing and commercializing it, as stated in their 2023 annual report. The user questions the effectiveness of KX-826 in comparison to minoxidil's role in improving hair thickness and appearance.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  21 upvotes 8 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community Anyone else crying themselves to sleep because of the pyrilutamide fail?

      in Technology  43 upvotes 11 months ago
      The conversation is about disappointment with pyrilutamide's performance as a hair loss treatment, with some users expressing interest in other treatments like Verteporfin, GT20029, and RU58841, while others suggest sticking with established treatments like finasteride or dutasteride.

      community Pyrilutamide phase III clinical trial results released

      in Research/Science  31 upvotes 11 months ago
      Pyrilutamide did not show effectiveness in regrowing hair compared to a placebo, but it may still help maintain existing hair by preventing DHT from causing follicle miniaturization. Some users believe it could be beneficial when used with other treatments like minoxidil, finasteride, and dutasteride.

      community Please explain this Minoxidil phenomena

      in Minoxidil  57 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Topical finasteride might be a lie

      in Research/Science 1 year ago
      The conversation discusses doubts about the effectiveness of topical finasteride for hair loss, suggesting that DHT could be produced elsewhere in the body and affect the scalp. It proposes that androgen receptor antagonists like spironolactone and clascoterone might be more effective as they could prevent this potential bypass mechanism.

      community Sublingual Minoxidil - Cure to Hairloss?

      in Minoxidil  583 upvotes 1 year ago
      The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

      community Progress pics April 30 to Aug 9

      in Progress Pictures  300 upvotes 1 year ago
      The user "mspamnamem" shares their progress with a hair loss treatment stack consisting of finasteride, minoxidil, biotin, and microneedling. They express satisfaction with their progress and hope for continued improvement. Other users in the conversation provide encouragement and share their own experiences.

      community Why is there more "fear" around on finasteride than around dutasteride

      in Chat  18 upvotes 1 year ago
      The conversation is about the comparison between finasteride and dutasteride for hair loss treatment. The conclusion is that there is more fear around finasteride due to its higher prevalence and being the first line of defense, while dutasteride is less commonly prescribed and used by those who have already tried finasteride without side effects.

      community RU58841 alone vs. with Fin / Dut

      in Finasteride/Dutasteride  11 upvotes 1 year ago
      RU58841 combined with finasteride or dutasteride is more effective than RU58841 alone for hair loss. Users suggest combining these with minoxidil and microneedling for better results.

      community Tricho test suggested topical spironolactone. Any experience with it?

      in Treatment  7 upvotes 1 year ago
      The conversation is about a person experiencing hair loss, using topical minoxidil for 8 years, now at Norwood scale 3, and considering topical spironolactone and oral minoxidil after a tricho test recommendation. They are seeking others' experiences with topical spironolactone.

      community Concerns about CosmeRNA safety mechanisms

      in Treatment  3 upvotes 1 year ago
      Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.

      community Overwhelming amount of anti-androgens

      in Female 1 year ago
      The conversation discusses the effectiveness of anti-androgens for hair loss, with a preference for topical treatments like RU58841 over oral options due to better scalp concentration and fewer side effects. Topical finasteride at 0.1% may provide some results, especially when combined with a topical androgen receptor antagonist like RU58841.

      community Since there is so much hype for cosmeRNA and HMI-115...

      in Chat  46 upvotes 1 year ago
      Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

      community AnagenInc says GT20029 is possible now

      in Research/Science  116 upvotes 1 year ago
      AnagenInc is ready to produce a hair loss treatment called GT20029 if there is enough demand. People are discussing combining it with other treatments like finasteride and minoxidil, and some are concerned about the legitimacy and safety of gray market products.

      community How effective is spironolactone?

      in Transgender  6 upvotes 2 years ago
      A 21-year-old MTF individual is experiencing rapid hair thinning and is currently on estradiol valerate. They are inquiring about the effectiveness of spironolactone for hair loss, despite being aware of its serious side effects.