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community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 month ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 138 upvotes 6 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Study of thousands of Fin users over 20 years finds no evidence of Fin induced sexual dysfunction

in Research/Science 370 upvotes 11 months ago

The conversation is about a finding that finasteride does not significantly increase the risk of sexual dysfunction, with users sharing mixed personal experiences regarding side effects.

community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 105 upvotes 3 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

community Can Soy Protein slowing down baldness?

in Research/Science 1 upvotes 1 year ago

Eating soy protein daily might slow down baldness due to its estrogen-stimulating effects. The user cannot use finasteride because it causes insomnia.

community Connection between finasteride and nafld?

in Research/Science 4 upvotes 5 months ago

Finasteride may affect liver function and cortisol levels, potentially linking it to non-alcoholic fatty liver disease (NAFLD). More research is needed to understand this connection fully.

community They've stopped selling this in the UK

in Ketoconazole 6 upvotes 7 months ago

Ketoconazole is no longer sold in the UK, and pharmacies have replaced it with non-ketoconazole options. Users are discussing its availability and possible alternatives.

community Anyone experienced weight gain on dutasteride?

in Finasteride/Dutasteride 6 upvotes 2 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 4 months ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

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