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GlossaryAnagen/Telogen Ratio

measure of hair follicles in growth vs. resting phases

The Anagen/Telogen Ratio is a measure used to assess hair growth and health by comparing the number of hair follicles in the anagen (growth) phase to those in the telogen (resting) phase. A higher ratio indicates a greater proportion of actively growing hair, which is typically a sign of healthy hair growth, while a lower ratio may suggest hair loss or a disruption in the hair growth cycle.

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community Scientific Review: Caffeine shampoo does NOT stop hair loss. False claims and "fake" research. 19 References included.

in Research/Science 205 upvotes 2 years ago

Alpecin Caffeine shampoo is ineffective for stopping hair loss, with unreliable supporting research. Finasteride is effective in reducing hair loss by lowering DHT levels.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 15 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Why haven’t we seen anything about this

in Research/Science 18 upvotes 4 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.

community My Dad seems to get his hair back?

in Question 17 upvotes 5 years ago

A user's father, mostly bald for 20 years, is regrowing hair using a serum called "Skrzypovita Serum Pro" without minoxidil. The user is curious about which ingredients might be causing hair growth.

community The Cure isn't 5 years away; it's already here.

in Research/Science 824 upvotes 1 day ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

community How does hair loss and recovery work?

in Chat 12 upvotes 3 months ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 37 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 103 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community 4 years; fin 1mg/day @ 4 years; minox twice daily @ 3 years; estradiol 5mg/day @ 3 months; spiro 100 mg /day @ 3 months (Wet hair because it's easy to hide issues with dry hair)

in Progress Pictures 198 upvotes 4 months ago

The user shared their 4-year hair regrowth progress using finasteride, minoxidil, estradiol, and spironolactone. They noted significant regrowth by the second year and additional benefits from estradiol and spironolactone.

community Fucking hell rosemary how is that possible

in Chat 19 upvotes 2 years ago

User reported hair regrowth and thicker hair after using rosemary oil, zinc, biotin, vitamin D, and a better diet. They believe rosemary oil contributed the most to the improvement.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Sandalore: a scientific homemade approch

20 upvotes 6 years ago

The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 668 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Next month marks 2 years on Dutasteride. When does it start working?

in Finasteride/Dutasteride 36 upvotes 7 months ago

A user has been on dutasteride for nearly 2 years with no improvement in hair loss, expressing frustration. Other users suggest checking for other health conditions, getting bloodwork, and considering stopping TRT or trying finasteride.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 206 upvotes 6 days ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Long term minoxidil as a permanent solution

in Minoxidil 27 upvotes 3 years ago

A user is considering using minoxidil for hair loss and asks for advice on application and long-term effectiveness. Responses suggest minoxidil can be effective but may lose efficiency over time, and combining it with other treatments like finasteride might be more beneficial.

community 3 and a half months on Fin MWF, min daily and microneedling once a week.

in Progress Pictures 681 upvotes 2 years ago

A user's progress with treating hair loss over 3.5 months, which involves taking finasteride MWF, minoxidil daily and microneedling once a week. There was positive feedback from other users regarding the results.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Coegin Pharma to release Follicopeptide (FOL005) by Q2 2025

in Treatment 117 upvotes 3 months ago

Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hair growth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.

community 16month progress on crazy stack

in Finasteride/Dutasteride 8 upvotes 1 year ago

The user has been using a strong combination of hair loss treatments for 16 months, including Finasteride, Minoxidil, Dutasteride, and RU-58841, but their hair loss has worsened. They're questioning whether their high testosterone levels or residual scalp DHT are causing further hair loss, with a reply suggesting that even small amounts of DHT can cause hair loss if one is sensitive to it.

community 1 month on min and derma pen every 10 days. Can you see a difference?

in Is this regrowth? 111 upvotes 3 months ago

A user has been using 5% minoxidil and a derma pen for one month, experiencing shedding but noticing potential new hair growth. They plan to add finasteride to their regimen.

community Kintor (Koshine Biomedica) changed their KX-826 pictures on Amazon to a alleged study picture after backlash over fake pictures

in Product 120 upvotes 5 months ago

Kintor changed their KX-826 pictures on Amazon after backlash over fake images. Users are skeptical about the product's effectiveness and trustworthiness, with some preferring finasteride instead.

community 14 Months on nuclear stack (0,5 DUT and 15mg oral Minox and no regrowth. Aga is impossible to beat

in Progress Pictures 1 year ago

The user has been on a hair loss treatment for 14 months using dutasteride and oral minoxidil without seeing regrowth and is considering adding more drugs due to the psychological impact of hair loss. However, replies suggest the user may not actually be experiencing noticeable hair loss.

community results in just 2 months🙏🙏19(M)

in Progress Pictures 72 upvotes 10 months ago

A 19-year-old user shared impressive hair growth results after using 5% topical minoxidil foam and 1mg finasteride for two months, along with vitamin D. They recommend this regimen for others, noting significant improvements in hair thickness and health.

community Can we trust l’oreal clinical study on Stemoxydine 5%? They conducted/founded the research on the Same molecule that they sell, research could be biased!? L’Oreal reported clinical study that showed an increase of 4% in hair density on the patients treated with stemoxydine for 3 months

in Research/Science 36 upvotes 2 years ago

Hair loss discussion includes treatments like Minoxidil, Finasteride, and RU58841. L'Oreal's study on Stemoxydine 5% claims a 4% increase in hair density after 3 months, but some users question potential bias.

community Should I stop or is this normal?

in Treatment 5 upvotes 4 months ago

Increased hair fall after starting minoxidil, dutasteride, and biotin is normal. Hair may grow faster, and shaving your head is fine while on these medications.

community TDM-105795 phase 2 results are in!

in Research/Science 28 upvotes 10 months ago

TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

community Quit Minoxidil, keep gains w/ Fin and Stemoxydine? | Self-experiment

in Minoxidil 54 upvotes 2 years ago

A user experimenting with quitting using Minoxidil and replacing it with Finasteride and Stemoxydine in order to keep hair loss gains, but other users warning the original poster of potential shedding. Another user suggested phasing out Minoxidil and replacing it with Finasteride and microneedling instead.

community Losing ground after 14 months of fin use and 11 months of min

in Finasteride/Dutasteride 51 upvotes 2 years ago

A 24-year-old person who is worried about their hair loss after 14 months of taking finasteride and 11 months of minoxidil. Replies to the post suggested sticking with their current regimen, that shedding from one part may not be telogen effluvium, and that shedding is normal with these drugs and they should evaluate in two to three months.