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RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

The post is about a user's progress in treating hair loss using HIMS FIN/MIN spray and dermarolling. One user suggests taking the 1mg finasteride pill instead of using the topical spray, while another warns against microneedling every day.

A user stopped using finasteride and switched to a mix of essential oils in jojoba oil to treat hair loss, which reduced itching and hair shedding significantly. They shared their experience, noting that dermatologists were not helpful.

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

The conversation discusses the effectiveness of a multivitamin containing Zinc, Biotin, B12, B6, B2, B1, Vitamin D, and Iron for hair loss. The multivitamin is from a reliable but inexpensive brand in Brazil.

The user experienced worsening hair loss despite using finasteride and dutasteride. They are considering trying minoxidil but are unsure if it will help.

The conversation is about a person experiencing significant hair loss in the donor area after a hair transplant, with others suggesting it might be shock loss. The person is taking oral minoxidil and dutasteride to help with the issue.

User has maintained hairline with minoxidil for 8 years but now seeks to add topical finasteride due to increased hair loss. They request advice on making a homemade finasteride solution, including ingredient recommendations and optimal percentages for ethanol and glycerin.

The conversation discusses whether oily scalp and sebum can hinder the absorption of topical hair loss treatments like Minoxidil and Finasteride, even when using tretinoin. The user is skeptical about the effectiveness of these treatments due to their oily scalp condition.

Tretinoin may help more minoxidil convert to its active form and could potentially increase its absorption, raising concerns about safety if too much enters the bloodstream. It's unclear if tretinoin affects finasteride absorption.

User asks if washing hair or using hair fibers after minoxidil dries is okay and if dry scalp means full absorption. Some doctors and sources say 50-75% absorption occurs after an hour.

User wonders if seborrheic dermatitis blocks absorption of topicals for hair loss. They use nizoral to improve the condition but it's not fully gone.

Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

User is on vacation in Greece and wants to buy tretinoin or isotretinoin to improve Minoxidil absorption. They are considering isotretinoin since it is available over-the-counter in Greece but requires a prescription back home.

The conversation is about using distilled water as a solvent for topical finasteride to reduce systemic absorption. The user is considering avoiding ethanol and propylene glycol to achieve this.

The user uses finasteride, minoxidil, and ketoconazole for hair loss. They are concerned if applying moisturizer before minoxidil affects its absorption or efficacy.

The conversation is about whether to use gloves when applying 5% RU58841 to avoid systemic absorption and if washing hands with water is sufficient. Users question the concern, noting it is applied to the scalp.

The conversation discusses using Actifolic tretinoin to enhance the absorption of Minoxidil for hair loss treatment. It questions the amount of tretinoin to use and whether to apply it before or after Minoxidil.

The conversation is about improving castor oil absorption for hair loss treatment. The user tried ethanol and sweet almond oil mixtures and plans to try DMSO next.

A user is using Fluridil for hair loss and is concerned that styling clay and powder might affect the absorption of the treatment. They apply clay in the morning and Fluridil in the evening and are considering switching to a styling powder.

A new topical Dutasteride with 20 times better scalp absorption being developed and tested for release in 2023; use of existing drugs, such as Minoxidil and finasteride; and mesotherapy as an alternative hair loss treatment.

Using a silicone scalp massager may help with dandruff and potentially improve the absorption of minoxidil and finasteride. The user has noticed peach fuzz growth after using minoxidil for over a month and finasteride for almost a month.

The post and conversation are about a hair loss treatment regimen involving 30% minoxidil cream nightly, 5% minoxidil in the mornings, finasteride, weekly 1.5 derma pen, daily 0.5 microneedling for minoxidil absorption, daily multivitamin with biotin, low-level laser therapy every other day, daily scalp massages, Hims shampoo, and daily coffee rinses. The user hopes for hair regrowth and plans to update in one year.

Tretinoin may increase minoxidil absorption but could potentially worsen hair loss over time. Users discuss applying 0.5% tretinoin gel to the hairline/scalp with minoxidil.

The conversation discusses the effectiveness and systemic absorption of Topilutamide/Fluridil/Eucapil and topical Dutasteride for hair loss. Users are sharing their experiences and seeking success stories with these treatments.

A user is considering microneedling to enhance absorption of a prescribed topical hair loss treatment containing Minoxidil, Dutasteride, and Latanoprost, while already taking oral Minoxidil and Dutasteride. They seek advice on the effectiveness and safety of combining these treatments, especially due to the cost and their desire to maximize results.

The conversation discusses enhancing Minoxidil absorption for hair loss treatment using Tretinoin and MSM (Methylsulfonylmethane). The user is seeking sources for Tretinoin and mentions MSM's potential to improve the absorption of topical agents.

A 25-year-old is using vinpocetine to enhance the absorption of topical Minoxidil for hair loss. They also use a hair tonic and supplement with Glycine, Taurine, Creatine, and Citrulline.

Topical minoxidil can cause increased body hair due to systemic absorption, varying by individual skin sensitivity. The user seeks experiences and solutions to prevent this side effect.

Topical finasteride with hydroxypropyl chitosan shows significantly less serum absorption and minimal DHT reduction compared to oral finasteride. Users need the specific chitosan formulation to avoid side effects seen with regular ethanol+PG solutions.