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Glossary5α-reductase inhibition (5AR inhibition)

blocking enzyme that converts testosterone to hair-loss hormone DHT

5α-reductase inhibition refers to the process of blocking the enzyme 5α-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). DHT is a hormone that can contribute to hair loss and conditions like benign prostatic hyperplasia. By inhibiting this enzyme, medications like finasteride and dutasteride can help reduce hair loss and treat these conditions.

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community will long term 5ar inhibition alter my physical appearance?

in Treatment 2 upvotes 3 months ago

A 19-year-old concerned about long-term effects of 5AR inhibitors on physical appearance. They have used finasteride and plan to try dutasteride or RU58841; responses suggest improved skin, hair, and confidence.

community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 105 upvotes 3 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 11 months ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Why are there no FDA approved NSAA's yet?

in Research/Science 6 months ago

The conversation discusses why there are no FDA-approved NSAAs like RU58841 on the market, despite their potential superiority to 5AR inhibitors like finasteride. It explores the effectiveness of treatments like Minoxidil, finasteride, and RU58841 for hair loss.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

in Treatment 8 upvotes 4 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community Shed switching from fin to dut?

in Finasteride/Dutasteride 10 upvotes 7 months ago

A user has been on finasteride for over 1.5 years but is still losing hair, so they're switching to dutasteride and taking both for 3 months before stopping finasteride. They're concerned about potential hair shedding during the switch even when done correctly.

community Serum DHT levels variation on dutasteride

in Treatment 1 year ago

Serum DHT levels and their variations when using dutasteride for hair loss treatment.

community 10 months’ hair-loss treatment progress – finasteride / dutasteride and minoxidil

in Progress Pictures 191 upvotes 2 years ago

User shares 10-month hair loss treatment progress using finasteride/dutasteride and minoxidil. Treatment shows positive results, with noticeable improvements in months 9 and 10.

community Began An Intensive Protocol but it's now all habit.

in Hair Systems 2 upvotes 2 years ago

The user follows an intensive hair loss protocol including dutasteride, biotin, black tea, pumpkin seed oil, peppermint shampoo, rosemary conditioner, mukemame, soy milk, lycopene, garlic, magnesium, chamomile, spicy food, citrus bergamot, zinc, multivitamins, kefir, and Greek yogurt. They plan to alternate between pumpkin seed oil and safflower oil and will share before and after pictures.

community Sulforaphane Topical to Degrade DHT - For People Who Want to Try the Theory that Explains Everything

in Treatment 38 upvotes 3 years ago

A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.

community Topical dutasteride, oral minoxidil, dermastamp, oral castor oil. Two months of difference

in Progress Pictures 7 upvotes 3 years ago

User sees subtle regrowth after two months using topical dutasteride, oral minoxidil, dermastamp, and oral castor oil. Others suggest waiting a few more months to properly evaluate results.

community Alfatradiol Experience (2 months)

in Treatment 12 upvotes 3 years ago

User experienced side effects from oral finasteride and tried topical Alfatradiol for hair loss. Alfatradiol provided maintenance without significant regrowth, and user suggests it as an alternative for those struggling with finasteride side effects.

community Why plain Azelaic acid is a safe and effective product for hairloss that makes Finasteride an obsolete treatment for male pattern baldness.

8 upvotes 10 years ago

The conversation discusses the effectiveness of Azelaic acid for hair loss, suggesting it may make Finasteride an outdated treatment for male pattern baldness. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community An argument for why we should take topical Dutasteride seriously

in Research/Science 85 upvotes 3 years ago

Topical Dutasteride may halt hair loss and effectively treat androgenic alopecia. Combining low-dose oral Dutasteride with topical application could maximize regrowth and minimize side effects.

community Woke up with the urge to cut all of it off

in Shaved/buzzed 31 upvotes 2 months ago

A user decided to buzz their thinning hair after starting Dutasteride, feeling liberated by the change. Other users shared similar experiences, with some using treatments like Finasteride and Minoxidil to manage hair loss.

community What all oils could be useful to augment hair growth

in Finasteride/Dutasteride 4 upvotes 5 months ago

The user uses 1mg fin every other day, a topical solution of 5% min + 0.1% fin nightly, and seeks advice on oils for hair growth. Replies suggest oils are ineffective and recommend sticking with fin and min treatments.

community Oral dutasteride vs topical efficacy

in Finasteride/Dutasteride 60 upvotes 6 months ago

The user switched from topical minoxidil/dutasteride to oral dutasteride, resulting in hair loss. They resumed topical treatment without regrowth and are considering switching to finasteride due to poor results with oral dutasteride.

community ghk-cu is potent 5-ar inhibitor?

in Product 10 upvotes 10 months ago

GHK-Cu is a potent inhibitor of the type 1 5-alpha reductase enzyme in hair follicles, which may reduce hair loss without the side effects associated with type 2 5-alpha reductase inhibitors. The user previously experienced side effects with 5-alpha reductase inhibitors and is considering GHK-Cu as an alternative.

community What’s the science behind 1mg Finasteride 3 X a week being as effective as daily?

in Finasteride/Dutasteride 19 upvotes 1 year ago

The efficacy of taking 1mg finasteride three times a week instead of daily for hair loss, with some users arguing that it is just as effective because finasteride has a long half-life in the scalp tissue and lower doses have been shown to be effective. Other users suggest experimenting with various treatments such as minoxidil and finasteride to achieve best results.

community 3 months of Min 2x daily, micro needling 1x weekly, and Ketoconazole shampoo 2-4x weekly. Definitely a big confidence boost and worth trying out!

in Progress Pictures 118 upvotes 2 years ago

The progress of a user who has been using Minoxidil, micro needling and ketoconazole shampoo for 3 months to improve their hair and confidence; other users have suggested different treatments such as DHT blockers or finasteride.

community My dermatologist didn't give me finasteride and instead gave me latanoprost and some cream

in Treatment 7 upvotes 3 years ago

User asked dermatologist for finasteride, received latanoprost and diprogenta cream instead. Others suggest latanoprost is expensive and not better than minoxidil, recommend trying another doctor for finasteride.

community A warning to those using or thinking about using Dutasteride – Follow-up

in Finasteride/Dutasteride 18 upvotes 3 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community Any experience on Natural DHT blocker?

in Research/Science 7 upvotes 4 years ago

The conversation is about using natural DHT blockers like saw palmetto, pumpkin seed oil, and stinging nettle extract for hair loss. Saw palmetto is noted to potentially halt mild hair loss.

community Another update. Almost a year on Dutasteride and Oral Minoxidil, after several years on finasteride and topical minoxidil. I’m fairly certain my hair is objectively worse than it was 5 months ago.

in Update 59 upvotes 1 year ago

A user's experience with hair loss treatments, including Dutasteride, Oral Minoxidil and Finasteride; potential side effects; and the potential of using anti-androgens or microneedling.

community 2 months topical dutasteride plus minoxidil, very happy with the results!

in Finasteride/Dutasteride 338 upvotes 3 years ago

A user's success in treating their hair loss with 2x daily topical dutasteride and minoxidil, as well as the potential for using less frequent application of topical dutasteride due to its long half-life.

community A warning to those thinking about using Dutasteride

in Finasteride/Dutasteride 99 upvotes 4 years ago

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.

community The Battle of Norwood (2024) | Dut 0.5 mg ED + Oral Min 5 mg ED

in Progress Pictures 505 upvotes 6 days ago

The conversation discusses hair regrowth using dutasteride and oral minoxidil, with the user reporting significant improvement in hair volume after combining these treatments. Some side effects mentioned include changes in libido and increased facial hair, but overall, the user is satisfied with the results.

community STOP LYING FOR LORD'S SAKE because you're misleading people who are trying their best

in Chat 185 upvotes 1 month ago

Some users believe people falsely claim hair restoration results from finasteride and minoxidil alone, while actually having hair transplants. Finasteride and minoxidil, often used with microneedling and nizoral, are effective for many, but results and opinions on dosages vary.