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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community High Nicotine use and Hair Loss

      in Chat  79 upvotes 3 months ago
      Heavy nicotine use can lead to hair thinning and loss, but quitting can reverse these effects. The user noticed significant hair regrowth after quitting vaping.

      community Excited to stack Finasteride+Kx826 😃

      in Research/Science  37 upvotes 3 months ago
      The conversation is about using finasteride and KX826 for hair loss treatment. The original poster is using 0.25 mg of finasteride every other day due to side effects at a higher dose.

      community Dim: high estradiol levels what to do

      in Chat  8 upvotes 4 months ago
      A user is experiencing facial bloating from low-dose topical finasteride due to high estradiol levels and is seeking advice on using DIM to manage this issue, including dosage and brand recommendations.

      community Dutasteride/finasteride theory

      in Finasteride/Dutasteride  5 upvotes 5 months ago
      Finasteride worked better for frontal scalp hair loss, while dutasteride helped the crown and mid-scalp but worsened the frontal area. The user shared personal experiences and invited open dialogue.

      community Anybody using topical melatonin or zix in 2024?

      in Chat  12 upvotes 5 months ago
      The conversation is about using topical melatonin or zix for hair loss without affecting hormones. The user is seeking advice on which treatment is more effective.

      community Dht test results after 1year oral dut

      in Treatment  12 upvotes 6 months ago
      The user is experiencing increased hair shedding after one year of using oral dutasteride. They are seeking opinions on their DHT test results, which show levels below baseline.

      community Which dermaroller do y'all use?

      in Microneedling  26 upvotes 6 months ago
      The conversation is about recommendations for microneedling tools for hair loss, with users suggesting a dermastamp from Koi Beauty and the Derminator 2 with 12-needle cartridges.

      community Does it work? Maneup GHK-Cu hair growth serum

      in Treatment  8 upvotes 6 months ago
      The conversation is about the effectiveness of Maneup GHK-Cu hair growth serum, a topical treatment for hair loss. The user is considering trying it but is skeptical due to issues others have had with DIY injections of a similar substance.

      community Progress? 1 month of minoxidil + microneedling

      in Is this regrowth?  11 upvotes 7 months ago
      The conversation discusses potential hair regrowth after one month of using minoxidil combined with microneedling. It's suggested that there might be progress, but one month is too soon to determine effectiveness.

      community Hair Transplant @ Hairtran Clinic (3545 Grafts) (~$3600USD)

      in Transplants  51 upvotes 8 months ago
      A user shared their positive hair transplant experience at Hairtran Clinic in Thailand, costing about $3600 for 3545 grafts, and mentioned being on oral finasteride and minoxidil for six months. Other users confirmed good results with the same clinic, noting it takes around six months to see significant improvement.

      community 1.5 years fin plus almost 3 years min, I think I’ve definitely made progress but I’m still not where I want to be, advice?

      in Progress Pictures  130 upvotes 10 months ago
      The user has been using finasteride for 1.5 years and minoxidil for almost 3 years for hair loss, and has seen some maintenance of hair but not significant regrowth. Suggestions from others include switching to dutasteride, trying oral minoxidil, and considering microneedling or hair fibers for better appearance.

      community New treatment? Minox + Bimatoprost

      in Treatment  6 upvotes 11 months ago
      A user discussed a new hair loss treatment combining 5% Minoxidil with Bimatoprost 0.3mg/ml, applied once daily. They referenced a study suggesting Bimatoprost may be more effective than Minoxidil.

      community I have been applying undiluted, pure 100% peppermint oil to my scalp, 2.5ml a day as an experiment

      in Treatment  92 upvotes 1 year ago
      A user is experimenting with applying undiluted peppermint oil to their scalp daily to stimulate hair growth, based on a rat study where peppermint oil outperformed minoxidil. The user reports immediate hair thickening and increased scalp blood flow, while others in the conversation express skepticism, humor, and concern about the undiluted application.

      community Red light therapy - research says they work, reviews say they don't - Turns out commercial device are severely under-powered, so could this actually work?

      in Technology  74 upvotes 1 year ago
      The conversation discusses the effectiveness of commercial Low-Level Laser Therapy (LLLT) devices for hair growth, suggesting they are underpowered compared to the ideal energy output shown in medical research. A user plans to build a custom helmet that meets the required specifications for effective treatment.

      community Clascoterone (Winlevi) now approved in Canada

      in Product  14 upvotes 1 year ago
      The conversation is about the approval of Clascoterone (Winlevi) in Canada for hair loss treatment. One user expressed skepticism about its effectiveness due to low concentration.

      community Pyrilutamide at 16 years old- update 2

      in Research/Science  21 upvotes 2 years ago
      A 16-year-old researching and trying Pyrilutamide for hair loss treatment, reporting back on side effects experienced after one week of use; the reported side effects included testicle pain, headache, and increased shedding. Libido and sexual performance seemed unaffected.