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Keratin

Protein forming hair, nails, and skin's outer layer

Keratin is one of a family of structural fibrous proteins also known as scleroproteins. It is the key structural material making up scales, hair, nails, feathers, horns, claws, hooves, and the outer layer of skin in tetrapod vertebrates. Keratin also protects epithelial cells from damage or stress. Keratin is extremely insoluble in water and organic solvents. Keratin monomers assemble into bundles to form intermediate filaments, which are tough and form strong unmineralized epidermal appendages found in reptiles, birds, amphibians, and mammals. Excessive keratinization participate in fortification of certain tissues such as in horns of cattle and rhinos, and armadillos' osteoderm. The only other biological matter known to approximate the toughness of keratinized tissue is chitin. Keratin comes in two types: the primitive, softer forms found in all vertebrates and the harder, derived forms found only among sauropsids.

Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

Research 10

  1. Keratins of the Human Hair FollicleInternational review of cytology · 2005 · 282 citations
  2. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical TrialJournal of Medicinal Food · 2017 · 50 citations
  3. Hair follicle-specific keratins and their diseasesExperimental Cell Research · 2007 · 156 citations
  4. Silver Sulfadiazine’s Effect on Keratin-19 Expression as Stem Cell Marker in Burn Wound HealingBiomedicine · 2020 · 11 citations
  5. Hair Keratins and Hair Follicle–Specific Epithelial KeratinsMethods in cell biology · 2004 · 31 citations
  6. Low Molecular Weight Collagen Peptide (LMWCP) Promotes Hair Growth by Activating the Wnt/GSK-3β/β-Catenin Signaling PathwayJournal of Microbiology and Biotechnology · 2023 · 15 citations
  7. The Catalog of Human Hair KeratinsJournal of Biological Chemistry · 2001 · 277 citations
  8. Targeted Follicular Delivery via Liposomal Encapsulation of Sesbania grandiflora - Enhances Hair and Scalp Health: A Randomized, Double-Blind, Placebo-Controlled Clinical StudyClinical Cosmetic and Investigational Dermatology · 2026
  9. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair RegrowthACS nano · 2019 · 304 citations
  10. Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.The Journal of Cell Biology · 1986 · 361 citations
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