Sodium Alginate Cross-Linked Hydroxypropyl Methylcellulose/Hydroxyapatite Nano Biomaterial Mediated with Zinc to Promote Bone Tissue Healing

The study developed a zinc-doped nanocomposite using sodium alginate, hydroxypropyl methylcellulose, and hydroxyapatite, aimed at promoting bone tissue healing. Characterization techniques confirmed the nanocomposite's size range of 80-200 nm and its non-cytotoxicity to MG63 cells. In vivo studies and molecular docking evaluations demonstrated effective bone targeting and osteogenesis properties, attributed to the nanocomposite's ability to block Farnesyl Diphosphate Synthetase in the mevalonate pathway, thereby inhibiting osteoclastic activity and promoting bone formation.