Yangyin Qingre Huoxue Method in Traditional Chinese Medicine Ameliorates Atherosclerosis in ApoE^−/− Mice Suffering from High-Fat Diet and HSP65 Aggression

The study examined the effects of the Yangyin Qingre Huoxue Prescription (YQHP) on atherosclerosis in ApoE−/− mice on a high-fat diet and exposed to HSP65 aggression. YQHP was found to regulate blood lipid levels, reduce inflammation, and modulate immune responses, particularly affecting Th17/Treg cell ratios and signaling pathways like IL-6-p-STAT3 and IL-2-p-STAT5. It showed similar efficacy to simvastatin in improving atherosclerotic lesions but with lower hepatotoxicity. The study, involving 5-6 mice per group, suggested YQHP as a promising alternative for atherosclerosis treatment due to its lipid-regulating and anti-inflammatory properties.