Genomic Surveillance Reveals The Rapid Expansion Of The XBB Lineage Among Circulating SARS-CoV-2 Omicron Lineages In Southeastern Wisconsin, USA

    September 2023 in “ Viruses ”
    Arunachalam Ramaiah, Manjeet Khubbar, Katherine Akinyemi, Amy Bauer, Francisco Carranza, Joshua Weiner, Sanjib Bhattacharyya, David Payne, Nandhakumar Balakrishnan
    TLDR The XBB lineage of the Omicron variant spread rapidly in Southeastern Wisconsin.
    The study conducted genomic surveillance of SARS-CoV-2 in Southeastern Wisconsin from November 2021 to April 2023, focusing on the rapid expansion of the XBB lineage among Omicron variants. Researchers analyzed 6,709 sequences and identified 357 lineages, with 88.8% belonging to Omicron. The XBB.1.5 sublineage, which showed 38 defining mutations, was particularly notable for its increased viral reproduction, transmission, and immune evasion. The study emphasized the importance of continuous genomic surveillance to guide public health interventions and manage COVID-19 transmission effectively.
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