Werner′s syndrome

Werner's syndrome, a rare hereditary condition characterized by accelerated aging post-puberty, was described in a 30-year-old female patient exhibiting symptoms such as baldness, premature graying, short stature, cataracts, and skin changes. The syndrome, inherited in an autosomal recessive manner, is linked to mutations in the WRN gene affecting DNA processes. Complications include arteriosclerosis and a heightened risk of various malignancies, notably fibrosarcoma. Diagnosis is crucial for early cancer detection, as life expectancy is reduced, with death often occurring due to myocardial infarction or cancer. Treatment is symptomatic, focusing on managing skin ulcers and cataracts, with vitamin C supplementation showing potential benefits.