The Scope and Use of Valproate in Epilepsy

March 1989 in “ PubMed ”

J. K. Penry, Jesse C. Dean

TLDR Valproate is effective for epilepsy but has side effects and requires careful monitoring.

Valproate emerged as a highly effective antiepileptic drug over the 15 years leading up to 1989, particularly for controlling generalized seizures as monotherapy. It was recommended to be administered in three to four doses daily due to its elimination half-life of 6 to 15 hours, which varied with other drugs and metabolic factors. While increasing dosage improved serum concentration levels, valproate also interacted with other medications, especially antiepileptic drugs. Notable side effects included tremor, weight gain, hair loss, hair growth, hepatotoxicity, and neural tube defects in offspring. Monitoring serum concentrations and seizure frequency was crucial for patient management.

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community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 52 upvotes 10 months ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

community Hey med experts explain this please??

in Research/Science 7 upvotes 3 months ago

Finasteride, dutasteride, saw palmetto, caffeine, spironolactone, acetyltetrapeptides, tea tree oil, hydrocortisone, zinc pyrithione, latanoprost, melatonin, marine protein supplements, PRP, microneedling, and valproate are discussed as treatments for hair loss. DHT reduction and inflammation control are key strategies.

community New & Improved Hair Growth Stack for Maximum Results

in Treatment 4 upvotes 10 months ago

A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

community Topical Valproic acid/sodium valproate — has anyone tried this?

in Question 2 upvotes 5 years ago

The conversation is about using valproic acid, an anti-seizure medication, as a topical treatment to promote hair growth. The original poster is seeking personal experiences from those who have tried this method.

community VDPHL-01 is Overrated and Ridiculous. This is just Oral Minoxidil.

in Research/Science 21 upvotes 10 months ago

VDPHL-01 is essentially a slow-release oral minoxidil, which is already known to work for hair growth. The formulation includes other ingredients like Medrogestone, Valproic acid, Setipiprant, and Cetirizine, but their effectiveness and necessity are questioned.

community 6 months before and after pics: VDPHL01 (oral minoxidil)

in Progress Pictures 111 upvotes 10 months ago

A user shared their positive experience with a clinical trial for a new oral medication, VDPHL01, which is a reformulated version of oral minoxidil taken at a high dose of 17mg daily, showing significant hair regrowth after six months. The user noted that this formulation is believed to be more effective and time-released, with fewer side effects compared to regular oral minoxidil.