TLDR Keratin 19 expression in certain skin cells is temporary and not a reliable stem cell marker.
The study observed that originally keratin-19-negative interfollicular epidermal cells transiently expressed keratin 19 and nuclear galectin-1 binding sites when induced by cell adhesion. These small cells resembled basal cells of the interfollicular epidermis or the bulge region of hair follicles. The research also noted that a population of cells highly positive for beta1 integrin, similar in size to keratin-19-positive cells, was resistant to terminal differentiation due to lack of anchorage. The findings suggested that keratin 19 expression, induced by cell adhesion, was temporary and should not be solely considered a marker of stem cell activity.
37 citations
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October 2009 in “Veterinary Dermatology” Canine hair follicles contain stem-like cells with high growth potential.
51 citations
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February 2004 in “Journal of Investigative Dermatology” The study investigated the expression of melanoma-associated chondroitin sulfate proteoglycan (MCSP) in human skin and hair follicles, identifying its presence in basal cells of the epidermis and the outer root sheath (ORS) of hair follicles. MCSP was found to colocalize with β1 integrin bright progenitor keratinocytes, suggesting its potential as a marker for epidermal stem cell populations. The study highlighted the complex nature of epithelial compartmentalization in the hair follicle, with MCSP expression being more intricate in the ORS compared to the interfollicular epidermis. The findings proposed that MCSP might play a role in regulating undifferentiated cell populations in the skin, although it was absent in more differentiated cells, and suggested potential implications for understanding hair growth and regeneration.
89 citations
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October 2003 in “Biology of the Cell” Galectin-1 helps in RNA processing in cell nuclei.
441 citations
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May 1996 in “Journal of Cell Science” Keratin 19 helps identify skin stem cells, with its presence varying by body location, age, and culture stage.
