Toxicity of Chlorinated Aromatic Compounds in Animals and Humans: In Vitro Approaches to Toxic Mechanisms and Risk Assessment
May 1985
in “
Environmental Health Perspectives
”
TLDR Chlorinated compounds like TCDD can cause skin issues and chloracne by affecting cell behavior.
The document discussed the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and its chlorinated analogs on human skin, leading to conditions such as acanthosis, hyperkeratosis, squamous metaplasia, and chloracne. It was found that the potential for these compounds to cause chloracne in animal models was linked to their affinity for the cytosolic TCDD receptor, which influences enzyme activities and cell proliferation and differentiation. The study focused on understanding the mechanisms of TCDD action in human epidermal cells and squamous cell carcinoma lines, aiming to develop a risk assessment model for these compounds using human cells.
