Comparative Study of Topical Sildenafil 2% and Topical Minoxidil 5% for Male Androgenic Alopecia Treatment

    April 2025 in “ Al-Azhar International Medical Journal /Al-Azhar International Medical Journal ”
    Mohammed Kotb Ibraheem, Mohammed Amer, Heidi M. Mansour, Yassir Hagag Mohammed Abd El Ati
    Image of study
    TLDR Minoxidil is the most common treatment for male hair loss, but sildenafil shows promise as an alternative.
    This study compared the efficacy of topical sildenafil 2% and topical minoxidil 5% in treating male androgenic alopecia (AGA) in 50 patients. Over six months, Group A used sildenafil and Group B used minoxidil. Results showed that minoxidil had a strong positive association with age and vertex hair thickness, while sildenafil showed significant positive associations with VH responses at the frontal region and patient satisfaction. Age and AGA duration negatively affected VH activity in the vertex region and frontal area hair thickness, but positively correlated with hair density in both regions. The study concluded that while minoxidil remains the most common treatment due to its tolerability and satisfaction, sildenafil presents a promising alternative.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community So depressed and upset with how much progress I’ve lost

      in Chat  51 upvotes 2 years ago
      A 20-year-old started taking finasteride for hair loss at 18, saw improvement, but developed erectile dysfunction (ED) after taking accutane. Despite stopping both medications, ED persisted, and hair loss worsened. Advice given includes considering tadalafil for ED, resuming finasteride, using minoxidil, and addressing psychological factors through positive thinking and lifestyle changes.

      community How many of you have significant others?

      in Shaved/buzzed  105 upvotes 2 years ago
      The conversation revolves around the experiences of different individuals with hair loss treatments like Minoxidil, Finasteride, and RU58841. The discussion includes various perspectives on the effects of these treatments, the importance of hair for self-esteem and attractiveness, and the influence of significant others on the decision to use or stop using these treatments.

      community My fin experience over 13+ years

      in Chat  150 upvotes 3 years ago
      The user's experience and success with taking finasteride to treat hair loss, which is confirmed by other users who have taken it without side effects. The user also advises that consulting a doctor before starting any kind of treatment for hair loss is important, as opposed to relying on self-made remedies available online.

      community How to BECOME a RESPONDER to Fin/Dut if you are not responding

      in Finasteride/Dutasteride  303 upvotes 2 years ago
      The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.

      community What is the ultimate hair regrowth protocol

      in Treatment  28 upvotes 7 months ago
      The conversation covers aggressive hair regrowth treatments like Dutasteride, Minoxidil (oral and topical), RU58841, microneedling, and ketoconazole shampoo. It also mentions PRP, laser therapy, GHK-Cu injections, and hormone therapy for maximum regrowth.

    Related Research

    2 / 2 results