The stiffness of the extracellular matrix is a key factor in tumor progression

The study highlights the critical role of the extracellular matrix (ECM) stiffness in tumor progression, particularly in basal cell carcinoma (BCC). It was found that the density and elasticity of type I collagen in the ECM can inhibit or facilitate BCC cell invasion, depending on the anatomical region. In mouse models, BCC cells in the ear, with sparse collagen networks, showed more aggressive invasion compared to those in the back, where denser collagen fibers impeded deeper tissue penetration. The research suggests that ECM properties, such as stiffness and composition, significantly influence cancer cell behavior and could guide future cancer treatment strategies. The study emphasizes the need for further research into ECM's role in various cancers and the potential for precision treatments targeting ECM characteristics.