The Sex-Linked Histocompatibility Antigens

    March 1958 in “ JNCI Journal of the National Cancer Institute ”
    Leo Sachs, E.D. Heller
    TLDR Male-to-female skin grafts in mice are rejected due to sex-linked antigens.
    The study investigated sex-linked histocompatibility antigens in 6 strains of mice, focusing on skin grafts and the immunological response. Male-to-female skin grafts were consistently rejected in all strains, indicating a strong immunological reaction, while other sex combinations were successful. The presence of these antigens was confirmed in various tissues, including liver and spleen. The study suggests that these antigenic differences could potentially be used to differentiate between X and Y chromosome-carrying sperm.
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